Search for dissertations about: "gold bio"

Showing result 1 - 5 of 40 swedish dissertations containing the words gold bio.

2. 1. Epitope mapping of antibodies towards human protein targets

   Author : Barbara Hjelm; Mathias Uhlén; Larry Gold; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibody; antibody validation; biomarker; epitope mapping; peptide array; proteomics; RBM3; staphylococcal surface display;

   Abstract : This thesis, based on five research papers, presents results from development and evaluation ofmethods for identifying the interaction site of antibodies on their antigens and the functional investigation of these in different assays. As antibodies have proven to be invaluable tools in diagnostics, therapy and basic research, the demand of characterizing these binding molecules has increased. READ MORE

4. 2. Engineering strategies for ABD-derived affinity proteins for therapeutic and diagnostic applications

   Author : Mikael Åstrand; Sophia Hober; John Löfblom; Larry Gold; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Protein G; ERBB2; ERBB3; Directed evolution; phage display; staphylococcal display; bispecific; Bioteknologi; Biotechnology;

   Abstract : Small stable protein domains are attractive scaffolds for engineering affinity proteins due to their high tolerance to mutagenesis without loosing structural integrity. The albuminbinding domain is a 5 kDa three-helix bundle derived from the bacterial receptor Protein G with low-nanomolar affinity to albumin. READ MORE

5. 3. Bioactive adsorbates on gold surfaces : structural properties and bio-interaction studies

   Author : Rodrigo Jr Petoral; Hans Siegbahn; Linköpings universitet; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP;

   Abstract : This thesis investigates the properties of biomolecular, model adsorbates on gold such as amino acid derivatives, peptides and related organic molecules. Subsequent bin-interaction studies were also conducted. READ MORE

6. 4. Synthesis of nanostructured and hierarchical materials for bio-applications

   Author : Fei Ye; Mamoun Muhammed; Andreas Fisher; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fe3O4; mSiO2; core-shell; MRI; multifunctional; PNIPAAm; LCST; gold; nanorod; nitric acid; AR; MDDC; biocompatibility; immunomodulation; Materials chemistry; Materialkemi;

   Abstract : In recent years, nanostructured materials incorporated with inorganic particles and polymers have attracted attention for simultaneous multifunctional biomedical applications. This thesis summarized three works, which are preparation of mesoporous silica coated superparamagnetic iron oxide (Fe3O4@mSiO2) nanoparticles (NPs) as magnetic resonance imaging T2 contrast agents, polymer grafted Fe3O4@mSiO2 NPs response to temperature change, synthesis and biocompatibility evaluation of high aspect ratio (AR) gold nanorods. READ MORE

7. 5. QCM-D – with focus on biosensing in biomolecular and cellular systems

   Author : Erik Nilebäck; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; QCM-D; biomolecular interactions; cell-surface interaction; glycosaminoglycans; viscoelasticity; cell morphology; Quartz crystal microbalance with dissipation monitoring; surface chemistry; protein conformation;

   Abstract : The high degree of complexity in biological systems is being investigated in greater and greater detail by increasingly sophisticated sensing approaches. The quartz crystal microbalance with dissipation monitoring (QCM-D) technique stands out in this context, by probing the viscoelastic properties at interfaces. READ MORE