Search for dissertations about: "granulysin"

Showing result 1 - 5 of 7 swedish dissertations containing the word granulysin.

2. 1. T cell and antibody responses in Plasmodium falciparum malaria and their relation to disease susceptibility

   Author : Salah Eldin Farouk; Marita Troye-Blomberg; Hannah Akuffo; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; P. falciparum; Malaria; Granulysin; Fulani; Schizont; Immunology; Immunologi;

   Abstract : Malaria antigen-induced polarization of T cells into effectors Th1 and/or Th2 cells and their subsequent release of cytokines is known to affect antibody production. This thesis includes studies on early innate responses to the parasite, with a focus on γδT cells, and acquired specific responses in African sympatric ethnic tribes. READ MORE

4. 2. Defense-peptides against mycobacteria

   Author : Charlotte M A Linde; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Antimicrobial peptides; NK-lysin; granulysin; PR-39; Mycobacterium;

   Abstract : Several members of the genus Mycobacterium can cause serious infections in both man and animal. One of the world's most serious infectious diseases, tuberculosis, is caused by the pathogen Mycobacterium tuberculosis. Specific defense to tuberculosis/mycobacteriosis is dependent on the individual's ability to mount a proficient immune response. READ MORE

5. 3. Local immune responses in tuberculosis : cytolytic effector functions at the site of mycobacterium tuberculosis infection

   Author : Sayma Rahman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Despite recent advances in tuberculosis (TB) research, shortage of knowledge still exists that limits the host-pathogen interactions in human TB. Cell-mediated immunity has been shown to confer protection in TB, although the relative importance of cytolytic T cells (CTLs) expressing granule-associated effector molecules perforin and granulysin is debated. READ MORE

6. 4. Genetic studies of familial hemophagocytic lymphohistiocytosis

   Author : Kim Göransdotter Ericson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Familial hemophagocytic lymphohistiocytosis FHL ; PRF1 gene; MUNC13-4 gene; NK cells; cytotoxic T lymphocytes;

   Abstract : The main contribution from this thesis is a refined knowledge of locus heterogeneity in familial hernophagocytic lympbohistiocytosis (FHL) and a further characterization of corresponding clinical and immunological phenotypes. Familial hemophagocytic lymphohistiocytosis is a fatal autosomal recessive immune deficiency clinically characterized by fever, cytopenia, hepatosplenomegaly, and hemophagocytosis. READ MORE

7. 5. T cell mediated immunity in malaria and mycobacterial infection : a protective role for gd+ T cells

   Author : Shewangizaw Worku; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Malaria; Plasmodium falciparum; Plasmodium. vivax; Mycobacteria; Mycobacterium tuberculosis; BCG; T lymphocytes; T cell receptor; [gamma][delta] T cells; [alpha][beta] T cells;

   Abstract : T cell mediated immunity is essential against intracellular infections. Studies of cell mediated immunity are important for the optimal design and development of effective vaccines. Identifying correlates of protective immunity will also enable measurement of vaccine efficiency. READ MORE