Search for dissertations about: "guinea pig lung"

Showing result 1 - 5 of 17 swedish dissertations containing the words guinea pig lung.

  2. 1. Development and regulation of alveolar fluid clearance in the guinea pig

    Author : Andreas Norlin; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; oxytocin-induced preterm labor; IRDS; fetal lung fluid; preterm lung development; amiloride-sensitive sodium channels; beta-adrenergic stimulation; alveolar epithelium; Animal physiology; Djurfysiologi;

    Abstract : Alveolar fluid clearance is driven by active absorption of Na+ across the alveolar epithelium. Development and hormonal regulation of alveolar fluid clearance over 1 hour was studied by instillation of a protein-containing, isosmolar fluid into lungs of fetal, newborn, and adult guinea pigs. READ MORE

  4. 2. Nitric oxide and eicosanoids : significance and interactions during antigen-induced responses in peripheral lung tissue

    Author : Anna-Karin Larsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Nitric oxide; leukotrienes; prostaglandins; histamine; ovalbumin; contractions; distal lung; rat; human; guinea pig; precision-cut lung slices; mast cell;

    Abstract : Asthma means difficulty in breathing and is described as a chronic, inflammatory disorder that produces narrowing of the lower respiratory tract. The allergen-induced asthmatic bronchoconstriction is primarily caused by an IgE-mediated release of the mast cell mediators, histamine and eicosanoids (leukotrienes and prostanoids). READ MORE

  5. 3. Experimental and Clinical Studies on Contact Allergy to Diphenylmethane-4,4′-diisocyanate and Related Substances

    Author : Haneen Hamada; Yrkes- och miljödermatologi; []
    Keywords : 4; 4′-MDI; freund s complete adjuvant; Guinea pig maximization test; 4; 4 -MDA; 4; 4 -DMDA; 4; 4 -DMDI; PPD; p-phenylenediamine; 2; 4-TDI; Toluene diisocyanate; trimer; FCA; Cross-reactivity; dermal uptake; contact allergy; contact dermatitis;

    Abstract : The exposure to isocyanates is more of an occupational problem than a consumer problem. The main route of exposure is assumed to be through inhalation. Isocyanates that have high vapor pressure, such as TDI, can be airborne at room temperature. Other isocyanates such as MDI are volatile only when heated. READ MORE

  6. 4. An experimental study of mediators in allergic bronchoconstriction with focus on eicosanoids

    Author : Ewa Selg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Leukotrienes; prostaglandins; histamine; guinea pig lung; ovalbumin; mast cell; cyclooxygenase; airway smooth muscle; COX inhibitors; NSAIDs;

    Abstract : Mast cells have a central role in the inflammatory response in airways of both atopic and non-atopic asthmatics. The mast cell-derived mediators such as histamine, leukotriene C4 and prostaglandin D2, released upon activation of the cell, produce acute bronchoconstriction that is characteristic of the early asthmatic response (EAR), and contribute to the development of airway inflammation and hyperresponsiveness following the initial reaction. READ MORE

  7. 5. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle

    Author : Eva Wikström Jonsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : cysteinyl leukotrienes; leukotriene receptor; histamine; antigen; smooth muscle; lipoxin; thromboxane; Schultz-Dale reaction;

    Abstract : The cysteinyl leukotrienes (leukotriene C4, D4 and E4) have potent biological actions which significantly contribute to the airway obstruction in asthma. Several of these effects are blocked by drugs known as CysLT1-receptor antagonists, which have been introduced as new treatment for asthma. READ MORE