Search for dissertations about: "h s"

Showing result 1 - 5 of 507 swedish dissertations containing the words h s.

2. 1. Experimental and Computational Predictions of Drug Solubility in Human Gastrointestinal Fluids

   Author : Jonas H. Fagerberg; Christel A. S. Bergström; Gert Ragnarsson; Bradley D. Anderson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : The aqueous solubility of a drug is viewed as a pivotal property for its oral absorption since only dissolved molecules can permeate the gut wall and reach the systemic circulation. The fluids in the intestine, however, do not only consist of water and therefore poor water solubility may not necessarily imply a poor solubility in the intestinal fluids and resulting low bioavailability. READ MORE

4. 2. Complement-mediated kidney diseases: Genotype, phenotype and inhibition studies

   Author : S.S. Aradottir; Lund Pediatrik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The complement system; factor B; factor D; danicopan; Atypical hemolytic uremic syndrome; C3 glomerulopathy; Membranoproliferative glomerulonephritis; genes; monozygotic twins;

   Abstract : Complement-mediated kidney diseases are ultrarare conditions characterized by excess complement activation related in most cases to complement gene variants or circulating autoantibodies. These conditions are chronic and can lead to kidney failure. READ MORE

5. 3. Risk and survival for colorectal cancer in northern Sweden : sociodemographic factors and surveillance programs

   Author : Olle Sjöström; Beatrice S. Melin; Lars H Lindholm; Richard Palmqvist; Johannes Blom; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; Risk factors; Cancer epidemiology; Endoscopy general; Health economy; Cancer prevention; Hereditary colorectal; Surveillance colonoscopy; Cancer Epidemiology; cancerepidemiologi; Genetics; genetik; Surgery; kirurgi; Oncology; onkologi;

   Abstract : BackgroundColorectal cancer (CRC) – i.e., cancer in the colon or rectum – is one of the most common cancers both globally and in Sweden. The risk for CRC is mainly related to age, heredity, and life-style risk factors. READ MORE

6. 4. Radio Resource Allocation and Utilization in Multiple Radio Access Networks

   Author : Georgios Koudouridis; Gunnar Karlsson; Frank H. P. Fitzek; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Abstract : Meeting in a sustainable way the demands of an unprecedented explosive growth in the number of connected devices and mobile data traffic, next-generation mobile networks are expected to make flexible use of spectrum and provide higher capacity by a denser deployment of radio access network infrastructure. In addition, the allocation and the utilisation of radio access resources should improve spectrum usage efficiency and keep energy consumption low, implying the capability to effectively exploit the denser deployment of radio accesses and the co-existence of radio accesses belonging to one or multiple radio access technologies. READ MORE

7. 5. Pharmacometric tools to support translational drug development

   Author : Rami Ayoun Alsoud; Ulrika S. H. Simonsson; Michael Lyons; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug development; pharmacometrics; pharmacokinetics; pharmacodynamics; non-linear mixed effect models; tuberculosis; dose selection; interspecies scaling; pediatric trials; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : The use of model-informed drug development has been shown to save significant costs and improve decision making early in the drug development process. The work in this PhD thesis aimed to employ pharmacometric tools to support translational drug development from the preclinical to the late clinical stages. READ MORE