Search for dissertations about: "hOB cells"

Showing result 1 - 5 of 7 swedish dissertations containing the words hOB cells.

  2. 1. The role of computer-aided design and surface chemistry on Cell-scaffold interactions

    Author : Sun Yang; Anna Finne-Wistrand; Ann-Christine Albertsson; Jinshan Pan; My Hedhammar; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amorphous degradable copolymer; aliphatic polyester; 3D fiber deposition; computer-aided design; Tween 80; BMSC; hOB; porous scaffolds;

    Abstract : Cell interactions and cell response to three dimensional scaffolds based on poly(L-lactide-co-1,5-dioxepan-2-one) [poly(LLA-co-DXO)] and poly(L-lactide-co-e-caprolactone) [poly(LLA-co-CL)] wereimprovedstudiedby increasing surface hydrophilicity and by using computer-aided scaffold design. Different amounts of Tween 80 (3, 10, 20 wt%) were mixed with the copolymer and it was found that the water contact angle decreased significantly with the amount of Tween 80. READ MORE

  4. 2. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Author : Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Keywords : hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Abstract : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. READ MORE

  5. 3. Expression and regulation of steroid metabolizing enzymes in cells of the nervous and skeletal systems : Special focus on vitamin D metabolism

    Author : Mokhtar Almokhtar; Maria Norlin; Kjell Wikvall; Gösta Eggertsen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Little is known about the mechanisms of vitamin D actions in the brain and bone. In this study, the metabolism of vitamin D and its regulation in various cell cultures of the nervous and skeletal systems were examined. READ MORE

  6. 4. The effects of some peptide hormones on osteoblast-like cells : with specific focus on oxytocin and vasopressin

    Author : Alena Lagumdzija; Karolinska Institutet; Karolinska Institutet; []
    Keywords : h0B; SaOS-2; OXT; AVP; IGF-I; PTH; PTHrP; eNOSKO;

    Abstract : The nonapeptides oxytocin (OXT) and vasopressin (AVP) are mainly produced in the hypothalamus and released into the circulation through the neurohypophysis. Recently, an OXT-receptor was demonstrated in human osteoblast-like (hOB) cells, and it has been suggested that patients with central diabetes insipidus (deficiency of AVP) have decreased bone mass. READ MORE

  7. 5. Experimental studies on the effects of insulin-like growth factor I and glucocorticoids on bone metabolism

    Author : Kenneth B. Jonsson; Uppsala universitet; []
    Keywords : Medical sciences; Bone; bone resorption; glucocorticoids; insulin-like growth factor I; osteoblasts; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Osteoporosis is a major cause of disability among patients that are dependent on glucocorticoids in the treatment of inflammatory disease. The pathogenesis behind this side effect is complex, involving dysregulation of hormonal systems and direct effects on bone cells. READ MORE