Search for dissertations about: "hcv IP-10"

Found 5 swedish dissertations containing the words hcv IP-10.

  2. 1. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

    Author : Jesper Waldenström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; HCV; Inosine triphosphate pyrophosphatase; ITPA; interferon-λ4; IFNL4; ribavirin; interferon; PWID; IP-10;

    Abstract : Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. READ MORE

  4. 2. Immunological and Genetic Markers Predicting Treatment Outcome in Hepatitits C Virus Infection

    Author : Galia Askarieh; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IP-10; CXCL10; CD26; hepatitis C virus; interferon; ribavirin; treatment; IL28B;

    Abstract : Hepatitis C is a blood-borne infection caused by the hepatitis C virus (HCV). A chronic infection, which develops in most infected subjects, may lead to liver cirrhosis with ensuing liver dysfunction and liver cancer. READ MORE

  5. 3. HIV-1/HCV co-infection : immunity and viral dynamics

    Author : Karolin Falconer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) are the agents behind two viral epidemics causing huge morbidity and mortality worldwide. HCV infection is a leading cause of end-stage liver disease. READ MORE

  6. 4. On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection

    Author : Åsa Alsiö; Göteborgs universitet; []
    Keywords : infectious diseases; virology; hepatitis c; treatment;

    Abstract : Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of considerable side effects and cost, shortened treatment duration without impaired efficacy is desirable. Thus, 382 genotype 2/3 infected patients were randomized in an investigator-initiated phase III study (NORDynamIC) evaluating the efficacy of 12 (short-term) vs. READ MORE

  7. 5. Immunoregulation by mononuclear phagocytes. Mechanisms and clinical implications

    Author : Ana Romero; Göteborgs universitet; []
    Keywords : ;

    Abstract : The cytotoxic effector lymphocytes of the immune system, the natural killer (NK) cells and the CD8+ T lymphocytes (CTL), have been ascribed a pivotal role in defense against malignancy. However, the function of these cells is frequently compromised, in particular at sites of malignant cell expansion. READ MORE