Search for dissertations about: "health bioinformatics"
Showing result 1 - 5 of 175 swedish dissertations containing the words health bioinformatics.
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1. Copy Number Analysis of Cancer
Abstract : By accurately describing cancer genomes, we may link genomic mutations to phenotypic effects and eventually treat cancer patients based on the molecular cause of their disease, rather than generalizing treatment based on cell morphology or tissue of origin.Alteration of DNA copy number is a driving mutational process in the formation and progression of cancer. READ MORE
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2. Development of Computational Methods for Cancer Research: Strategies for closing the feedback loop in omics workflows
Abstract : As the ultimate workhorses of the living things, proteins undergo significant regulatory activity throughout the lifetime of a cell or an organism. Many complex diseases effect the protein composition, expression or modification in the cells or tissues they arise in. READ MORE
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3. In vitro toxicity testing using human pluripotent stem cell derivatives
Abstract : .... READ MORE
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4. Human leukocyte antigen in sickness and in health : Ankylosing spondylitis and HLA in Sweden
Abstract : The human leukocyte antigen (HLA) plays a major role in keeping us healthy, but some of the HLA alleles can contribute to disease susceptibility. One example is HLA-B*27, which confers increased susceptibility of ankylosing spondylitis and represents one of the strongest genetic associations found in any common human disease. READ MORE
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5. Regulation of Gene Expression in Multiple Myeloma Cells and Normal Fibroblasts : Integrative Bioinformatic and Experimental Approaches
Abstract : The work presented in this thesis applies integrative genomic and experimental approaches to investigate mechanisms involved in regulation of gene expression in the context of disease and normal cell biology.In papers I and II, we have explored the role of epigenetic regulation of gene expression in multiple myeloma (MM). READ MORE