Search for dissertations about: "heme biosynthesis"

Showing result 1 - 5 of 25 swedish dissertations containing the words heme biosynthesis.

  2. 1. Porphyrins and heme in microorganisms : Porphyrin content and its relation to phototherapy and antimicrobial treatments in vivo and in vitro

    Author : Jonas Fyrestam; Conny Östman; Jonas Bergquist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Porphyrins; heme; phototherapy; antimicrobial resistance; singlet oxygen; photosensitizer; bacteria; HPLC-MS MS; oral bacteria; Aggregatibacter actinomycetemcomitans; Porphyromonas gingivalis; Escherichia coli; Analytical Chemistry; analytisk kemi;

    Abstract : One of the greatest threats to human health is increasing antimicrobial resistance among pathogens, and finding alternatives for treatment of bacterial infections is of highest importance together with a more controlled use of antibiotics. Porphyrins and heme have both been shown to be a promising class of compounds for inactivation of bacteria; porphyrins by their excellent properties to act as a photosensitizer, and heme by its importance as an iron source during a bacterial infection in vertebrates. READ MORE

  4. 2. Synthesis of hemes found in heme-copper oxidases of Bacillus subtilis

    Author : Mimmi Throne-Holst; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Biologi; Biology; heme biosynthesis; respiratory oxidase; cytochrome; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : The last step of aerobic respiration, the reduction of dioxygen to water, is catalysed by terminal oxidases. These oxidases can be divided into two unrelated families, the heme-copper oxidases and the cytochrome bd-type oxidases. These enzymes contain two or more heme molecules as prosthetic groups. READ MORE

  5. 3. Ferrochelatase and Magnesiumchelatase: Metal chelation studied with mutants

    Author : Ulf Olsson; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; chlorophyll; heme; barley; mutants; Magnesium chelatase; ferrochelatase; Metabolism; Biokemi; metabolism;

    Abstract : Magnesium chelatase and ferrochelatase are two very important enzymes, which are involved in chlorophyll and heme biosynthesis, respectively. They both use protoporphyrin IX as substrate but magnesium chelatase inserts a magnesium ion whereas ferrochelatase inserts a ferrous ion. These two enzymes have been studied in this thesis. READ MORE

  6. 4. Enzymatic metal-chelation by porphyrins

    Author : Andreas Hansson; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; tetrapyrrole; Plant biochemistry; Växtbiokemi; MIDAS; metallation; magnesium chelatase; integrin; heme; ferrochelatase; chlorophyll; barley; AAA ; ATPase;

    Abstract : This thesis deals with the structure and function of two different enzymes, ferrochelatase and magnesium chelatase, that catalyse similar reactions. When this work started, a three-dimensional model of ferrochelatase existed. Much was known about the enzyme, but some details remained unclear. READ MORE

  7. 5. Structural and physicochemical studies on metal and porphyrin binding by the Bacillus subtilis ferrochelatase

    Author : Mattias Hansson; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; metal specificity; metal binding; porphyrin metallation; time resolved crystallography; fluorescence quenching; X-ray structure; inclusion bodies; Bacillus subtilis; heme biosynthesis; ferrochelatase; hemH;

    Abstract : The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. READ MORE