Search for dissertations about: "hepatic lesions"

Showing result 1 - 5 of 16 swedish dissertations containing the words hepatic lesions.

  2. 1. Studies on the regulation of hepatic and intestinal lipid metabolism

    Author : Kristina Kannisto; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Disturbances in the lipid homeostasis can result in a wide variety of different diseases and symptoms. This thesis is focused on the regulation of cholesterol metabolism and its relation to atherosclerosis development, and the effect of mitochondrial (mt)DNA depletion on hepatic β-oxidation of fatty acids. READ MORE

  4. 2. The role of PPARalpha and growth hormone in hepatic lipid metaboism and atherosclerosis

    Author : Anna Ljungberg; Göteborgs universitet; []
    Keywords : growth hormone; PPARalpha; atherosclerosis; lipid metabolism; fatty acids; apoB; ; ADRP; triglycerides; PGC-1; liver;

    Abstract : Dyslipidemia mainly results from oversecretion of apoB-containing lipoproteins from theliver and is one of the most important risk factors for the development of atherosclerosis.Growth hormone (GH) plays a key role in the regulation of lipoprotein metabolism and thus,disturbances in GH secretion are associated with dyslipidemia and cardiovascular disease. READ MORE

  5. 3. Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone

    Author : Paolo Parini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : aging; atherosclerosis; bile acids; estrogen; estrogen receptor; cholesterol; growth hormone; growth hormone receptor; cholesterol 7[alpha]-hydroxylase; high density lipoprotein; hydroxy-methylglutaryl-coenzyme A reductase; hormones; hypercholesterolemia; hypophysectomy; insulin-like growth factor-I; low density lipoproteins;

    Abstract : Coronary heart disease is the result of the progression of atherosclerotic lesions, and represents the major cause of death in western countries. Age, male sex, plasma cholesterol, hypertension and smoking are major risk factors for atherosclerosis. READ MORE

  6. 4. Liver tumour promoting effects by polychlorinated biphenyls

    Author : Marie Haag Grönlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : tumour promotion; altered hepatic foci; rat liver; PCB; potency; TEF; interactions; antagonism; biologically based cancer growth models; TCDD;

    Abstract : PCBs cause a number of toxic effects and are present in a variety of biological samples including fish, meat and diary products. Cancer is a serious toxic effect by PCBs that has been observed in animal experiments but the knowledge about PCB induced carcinogenicity is still scarce. READ MORE

  7. 5. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci

    Author : Niklas Finnberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Enzyme-altered foci; p53; ATM; diethylnitrosamine; phenobarbital; liver; gene dosage;

    Abstract : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). READ MORE