Search for dissertations about: "hepatic stellate cells"

Showing result 1 - 5 of 17 swedish dissertations containing the words hepatic stellate cells.

  2. 1. The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems

    Author : Åsa Kolterud; Leif Carlsson; Stefan Thor; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; LIM-homeobox gene; Lhx2; fetal liver; hepatic stellate cells; hematopoietic stem cells; septum transversum; self-renewal; odorant receptor genes; olfactory epithelium; olfactory sensory neuron; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Abstract : During embryonic development a variety of tissues and organs such as the lung, eye, and kidney are being formed. The generation of functional organs is regulated by reciprocal cell-cell interactions. Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. READ MORE

  4. 2. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A storage in rat hepatic stellate cells

    Author : Annika Hanberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dioxin; TCDD; vitamin A; retinoids; lecithin:retinol acyltransferase; absorption; stellate celL hepatic vitamin A accumulation; intestinal lymph collectionDoctoral Thesis 1996 Annika Hanberg;

    Abstract : The polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), popularly called dioxins, are persistent pollutants with widespread occurrence in the environment as well as in human food and tissues. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin, as well as other dioxin-like compounds induce a broad spectrum of biochemical and toxic effects, many of which occur at extremely low doses or concentrations. READ MORE

  5. 3. Cellular and molecular mechanisms in immune mediated hepatic fibrosis. A study of the inflammatory syndrome and fibrosis development of the NIF mouse liver

    Author : Julia Nilsson; Autoimmunitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; liver; mouse model; NKT cells; type 2 inflammation; inflammasome;

    Abstract : Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. READ MORE

  6. 4. The role of Lhx2 in the hematopoietic stem cell function, liver development and disease

    Author : Ewa Wandzioch; Leif Carlsson; Stephen A Duncan; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; liver fibrosis; liver development; Lhx2; hematopoietic stem cells; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molecular cell biology; molekylär cellbiologi;

    Abstract : During embryonic development, generation of functional organs is dependent on proper interactions between different cell types. Elucidation of the mechanisms operating during organ formation might provide insights into the origin of many pathological disorders in the adult. READ MORE

  7. 5. Proteomic and Functional Analysis of In Vitro Systems for Studies of Drug Disposition in the Human Small Intestine and Liver

    Author : Magnus Ölander; Per Artursson; Pär Matsson; Edward L. LeCluyse; Volker Lauschke; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; drug disposition; ADMET; drug transport; drug metabolism; hepatotoxicity; small intestine; liver; caco-2; human hepatocytes; cryopreservation; apoptosis; liver zonation; non-parenchymal cells; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : To reach the bloodstream, an orally administered drug must be absorbed through the small intestine and avoid extensive clearance in the liver. Estimating these parameters in vitro is therefore important in drug discovery and development. READ MORE