Search for dissertations about: "hepatotoxicity"

Showing result 1 - 5 of 23 swedish dissertations containing the word hepatotoxicity.

  2. 1. Drug and alcohol induced hepatotoxicity

    Author : Angelica Butura; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatotoxicity; in vitro models; alcoholic liver disease; CYP2E1;

    Abstract : Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) causes a further substantial amount of liver insufficiencies world wide. READ MORE

  4. 2. Studies of drug safety in the treatment of rheumatoid arthritis

    Author : Johanna Karlsson Sundbaum; Eva Baecklund; Mia Wadelius; Pär Hallberg; Peter Michaelson; Gerd-Marie Alenius; Uppsala universitet; []
    Keywords : Drug safety; Rheumatoid arthritis; Hepatotoxicity; Methotrexate; MTHFR; GWAS; tuberculosis; screening;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting mainly smaller joints. Patients are at risk for complications as joint destruction, but starting treatment soon after onset of disease, has reduced the risk for complications. READ MORE

  5. 3. Proteomics informed investigation of human hepatocytes and liver tissue

    Author : Niklas Handin; Per Artursson; Peter Nygren; Tobias Sjöblom; Mårten Fryknäs; Pieter Annaert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; liver; hepatocytes; proteomics; cellular stress; apoptosis; hepatotoxicity; 3D culture; spheroid; drug metabolism; drug toxicity; drug transport; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. READ MORE

  6. 4. Proteomic and Functional Analysis of In Vitro Systems for Studies of Drug Disposition in the Human Small Intestine and Liver

    Author : Magnus Ölander; Per Artursson; Pär Matsson; Edward L. LeCluyse; Volker Lauschke; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; drug disposition; ADMET; drug transport; drug metabolism; hepatotoxicity; small intestine; liver; caco-2; human hepatocytes; cryopreservation; apoptosis; liver zonation; non-parenchymal cells; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : To reach the bloodstream, an orally administered drug must be absorbed through the small intestine and avoid extensive clearance in the liver. Estimating these parameters in vitro is therefore important in drug discovery and development. READ MORE

  7. 5. Studies on genetic hemochromatosis and the hepatotoxicity of iron

    Author : Karin Hagen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this study was to investigate the mutations and clinical expression of genetic hemochromatosis in patients and mechanisms involved in the hepatotoxicity of iron in animal and cell- culture models. In Swedish patients with a clinical diagnosis of genetic hemochromatosis, the C282Y mutation of the HFE gene was present in 94. READ MORE