Search for dissertations about: "heterocyclic aromatic amines"

Found 5 swedish dissertations containing the words heterocyclic aromatic amines.

2. 1. Aromatic Allylation via Diazotization; Application in synthesis of heterocyclic compounds

   Author : Fredrik Ek; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bengamide analogue.; parallel synthesis; trimethylsilyl azide; cycloaddition; imidazole; fused tetrazole derivatives; iodocyclization; benzazepine; tert-butyl nitrite; allylic bromide; aromatic allylation; diazotization; Organic chemistry; Organisk kemi;

   Abstract : A new method for allylation of aromatic systems has been developed. A number of arylamines were converted via diazotization to the corresponding allylaromatic compounds using tert-butyl nitrite and an excess of allylic bromides with complete regioselectivity. Electron-withdrawing groups, in the aromatic moiety, were necessary to obtain good yields. READ MORE

4. 2. Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles

   Author : Marika I Kleman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : heterocyclic aromatic amine; indolocarbazole; dioxin receptor; CYPlA;

   Abstract : Cooking of protein-rich food generates procarcinogenic heterocyclic aromatic amines(HCA) in amounts that range in the part per billion levels. The capacity of the two most prevalent HCA, PhIP and MelQx, to induce genetic alterations in vivo was determined using a short-term liver carcinogenesis model (RH-model) in rat. READ MORE

5. 3. Capillary electroseparations with mass spectrometric detection Nanoparticle-based continuous full filling and applications for complex sample matrices

   Author : Peter Viberg; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytisk kemi; Analytical chemistry; phthalates; continuous full filling; heterocyclic aromatic amines; pseudostationary phase; capillary electrophoresis; electrokinetic chromatography; capillary electrochromatography; nanoelectrospray; mass spectrometry;

   Abstract : One of the major challenges in analytical chemistry is to find techniques and methods for determinations of low abundance compounds in complex sample matrices. This thesis describes the development of new miniaturised analytical techniques comprising capillary electroseparation combined with mass spectrometric detection. READ MORE

6. 4. Transition metal-catalyzed reduction of carbonyl compounds : Fe, Ru and Rh complexes as powerful hydride mediators

   Author : Elina Buitrago; Hans Adolfsson; Robert Morris; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric catalysis; amino acid; N-heterocyclic carbene; iron; ruthenium; rhodium; mechanistic investigation; kinetic study; asymmetric transfer hydrogenation; hydrosilylation; organisk kemi; Organic Chemistry;

   Abstract : A detailed mechanistic investigation of the previously reported ruthenium pseudo-dipeptide-catalyzed asymmetric transfer hydrogenation (ATH) of aromatic ketones was performed. It was found that the addition of alkali metals has a large influence on both the reaction rate and the selectivity, and that the rate of the reaction was substantially increased when THF was used as a co-solvent. READ MORE

7. 5. Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells

   Author : Mirjam Nordling; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Polycyclic aromatic hydrocarbons; benzo[a]pyrene; colon cancer; genotoxicity; oxidative DNA damage.;

   Abstract : Cancer of the colon and rectum is the third most common cancer form in the world. Where the majority of cases fall into the category of sporadic colorectal cancer (CRC), lifestyle and diet have been found to be important risk factors associated with CRC. READ MORE