Search for dissertations about: "histone H4 methylation"

Showing result 1 - 5 of 8 swedish dissertations containing the words histone H4 methylation.

2. 1. Chromatin, histones, and epigenetic tags

   Author : Elisavet Koutzamani; Ingemar Rundquist; Herbert Lindner; Sergey Belikov; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromatin; histones; histone variants; epigenetics; histone H4 methylation; linker histone phosphorylation; Medical cell biology; Medicinsk cellbiologi;

   Abstract : The fundamental building blocks of chromatin are the nucleosomes. Each such unit is composed of about 200 bp of DNA, the well-conserved core histones (H2A, H2B, H3 and H4) and a linker histone (H1). READ MORE

4. 2. Genome-wide patterns of histone modifications in fission yeast

   Author : Indranil Sinha; Karl Ekwall; Karin Dahlman-Wright; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : DNA is wrapped almost two times around a group of proteins called histones to form a chromosomal structure known as the nucleosome. Both DNA and histones can be modified with different chemical tags by several enzymes to activate or suppress a particular gene or group of genes. Histones can be covalently modified at several places. READ MORE

5. 3. The oncogenic role of histone chaperone ASF1 proteins in solid tumors

   Author : Yujiao Wu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Chromatin is the essential medium connecting regulatory signals such as transcription factors and signaling pathways to the alteration of gene activity and cellular phenotypes. Aberrant chromatin (epigenetic) environment plays an important role in carcinogenesis. READ MORE

6. 4. On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate

   Author : Karolina Wallenborg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist of two subunits of each core histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. READ MORE

7. 5. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells

   Author : Veronika Viktorija Borutinskaite; Karl Eric Magnusson; Ruta Navakauskiene; Tor Olofsson; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; leukemia; histone deacetylase inhibitors; retinoic acid; differentiation; apoptosis; Cell and molecular biology; Cell- och molekylärbiologi;

   Abstract : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. READ MORE