Search for dissertations about: "histone deacetylation"

Showing result 1 - 5 of 10 swedish dissertations containing the words histone deacetylation.

  2. 1. Mechanisms of Transgene Silencing in Neural Cells -Implications for Ex Vivo Gene Therapy to the Brain

    Author : Nina Rosenqvist; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; Neurology; neuropsychology; ChIP; rat; transgene; insulator; differentiation; GFP; lentivirus; DNA methylation; histone deacetylation; chromatin; expression; silencing; stem cell; progenitor; gene therapy; neurofysiologi; neuropsykologi; CNS; transplantation;

    Abstract : The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. READ MORE

  4. 2. Transcriptional regulation of the Epstein-Barr virus latent membrane protein 1 gene in B cells

    Author : Weiwen Yang; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; B-cell; transformation; LMP1; LRS; EBNA2; transcription; transactivation; repression; histone deacytylation;

    Abstract : Epstein-Barr Virus (EBV) is a ubiquitous human B-lymphotrobic herpesvirus that latently infects over 90 percent of the world´s population. EBV infection is usually benign in healthy people. READ MORE

  5. 3. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells

    Author : Veronika Viktorija Borutinskaite; Karl Eric Magnusson; Ruta Navakauskiene; Tor Olofsson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; leukemia; histone deacetylase inhibitors; retinoic acid; differentiation; apoptosis; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. READ MORE

  6. 4. Characterisation of CtBP : A Co-Repressor of Transcription that Interacts with the Adenovirus E1A Protein

    Author : Anders Sundqvist; Anthony Wright; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; CtBP; HDAC; adenovirus; E1A; gene expression; repression; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Abstract : In this study, adenovirus E1A has been used to target and analyse the transcriptional function of the cellular C-terminal Binding Protein (CtBP).Transcription is a complex biochemical process that represents a major regulatory step in gene expression. READ MORE

  7. 5. Chromatin regulators and transcriptional control of Drosophila development

    Author : Qi Dai; Mattias Mannervik; Albert J. Courey; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chromatin; Co-factors; Transcription; Development; Drosophila; Developmental biology; Utvecklingsbiologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : The development of a multicellular organism is programmed by complex patterns of gene expression. In eukaryotic cells, genes are packaged by histone proteins into chromatin. Chromatin regulators often function as transcription co-factors. READ MORE