Search for dissertations about: "histone modifications"

Showing result 1 - 5 of 77 swedish dissertations containing the words histone modifications.

  2. 1. Jack of all trades, master of none : the multifaceted nature of H3K36 methylation

    Author : Henrik Lindehell; Jan Larsson; Anders Byström; Peter B. Becker; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; H3K36; histone methylation; dosage compensation; chromosome-specific gene regulation; transposable elements; PIWI piRNA biosynthesis; Set2; Ash1; NSD; Histone 3.3; post-translational modifications; histone modifications; epigenetics; proximity ligation assay; Drosophila; Genetics; genetik; molekylärbiologi; Molecular Biology; Biopharmaceutics; biofarmaci;

    Abstract : Post-translational modifications of histones enable differential transcriptional control of the genome between cell types and developmental stages, and in response to environmental factors. The methylation of Histone 3 Lysine 36 (H3K36) is one the most complex and well-studied histone modifications and is known to be involved in a wide range of molecular processes. READ MORE

  4. 2. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach

    Author : Santhilal Subhash; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Long noncoding RNAs; Chromatin; S-phase; Cell cycle; sperm; Epigenetics; Histone; cancer; oncogene; Tumor suppressor; DNA methylation; Histone modifications; Chromatin remodelers; lncRNAs; lincRNAs;

    Abstract : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. READ MORE

  5. 3. Clinical management of pancreatic cancer aided by histone signatures

    Author : Monika Bauden; Lund Kirurgi; []
    Keywords : Pancreatic cancer; Histone modifications; Tumor size; Biomarkers; Tumor; LC MS MS; Nucleosomics; Histone H1.3;

    Abstract : .... READ MORE

  6. 4. Chromatin structure and histone modifications in gene regulation

    Author : Carolina Åstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In the living cell, DNA is densely packed into a chromatin structure constituting nucleosomal arrays. One nucleosome core particle includes a disc shaped protein octamer consisting of pairs of histones H2A, H2B, H3 and H4. 146 bp of DNA is wrapped in almost two turns around this protein complex. READ MORE

  7. 5. Chromatin, histones, and epigenetic tags

    Author : Elisavet Koutzamani; Ingemar Rundquist; Herbert Lindner; Sergey Belikov; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromatin; histones; histone variants; epigenetics; histone H4 methylation; linker histone phosphorylation; Medical cell biology; Medicinsk cellbiologi;

    Abstract : The fundamental building blocks of chromatin are the nucleosomes. Each such unit is composed of about 200 bp of DNA, the well-conserved core histones (H2A, H2B, H3 and H4) and a linker histone (H1). READ MORE