Search for dissertations about: "histone variants"

Showing result 1 - 5 of 17 swedish dissertations containing the words histone variants.

2. 1. Histone H1 : Subtypes and phosphorylation in cell life and death

   Author : Anna Gréen; Ingemar Rundquist; Peter Söderkvist; Rolf Ohlsson; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; Cellbiologi;

   Abstract : The genetic information of a human diploid cell is contained within approximately 2 metres of linear DNA. The DNA molecules are compacted and organized in various ways to fit inside the cell nucleus. Various kinds of histones are involved in this compaction. One of these histones, histone H1 is the topic of the present thesis. READ MORE

4. 2. Chromatin, histones, and epigenetic tags

   Author : Elisavet Koutzamani; Ingemar Rundquist; Herbert Lindner; Sergey Belikov; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromatin; histones; histone variants; epigenetics; histone H4 methylation; linker histone phosphorylation; Medical cell biology; Medicinsk cellbiologi;

   Abstract : The fundamental building blocks of chromatin are the nucleosomes. Each such unit is composed of about 200 bp of DNA, the well-conserved core histones (H2A, H2B, H3 and H4) and a linker histone (H1). READ MORE

5. 3. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression

   Author : Eshagh Dorafshan Esfahani; Yuri B. Schwartz; Jan Larsson; Dale Dorsett; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Trithorax Group proteins; Polycomb Group proteins; PRC1; PRC2; PRE; histone methylation; histone ubiquitylation; Ash1; SET domain; H3K36; H3K27; Drosophila;

   Abstract : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. READ MORE

6. 4. Epigenetic Mapping in Type 2 Diabetes. Glucose-triggered histone modifications in various tissues

   Author : Bompada Pradeep; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; epigenetics; histone modifications; genome editing; ChIP-seq; RNA-seq; pancreatic islets; diabetic kidney disease; peripheral blood mononuclear cells; atherosclerosis;

   Abstract : Epigenetic modifications triggered by high glucose may predispose to diabetes risk by regulating gene expression activity. A growing body of evidence suggests that histone modification which is an essential component of epigenetic mechanism may play an important role in the development of type 2 diabetes (T2D) and its complications. READ MORE

7. 5. Array-based Genomic and Epigenomic Studies in Healthy Individuals and Endocrine Tumours

   Author : Johanna Sandgren; Gunnar Westin; Teresita Diaz de Ståhl; Göran Åkerström; Ola Hessman; Winand Dinjens; Uppsala universitet; []
   Keywords : genome; copy number variants; cancer; Pheochromocytoma; epigenome; array-CGH; ChIP-chip; gene expression; tumour suppressor genes; oncogenes; MEDICINE; MEDICIN; Kirurgi; Surgery;

   Abstract : The human genome is a dynamic structure, recently recognized to present with significant large-scale structural variation. DNA-copy number changes represent one common type of such variation and is found both between individuals and within the somatic cells of the same individual, especially in disease states like cancer. READ MORE