Search for dissertations about: "histone"

Showing result 1 - 5 of 284 swedish dissertations containing the word histone.

  2. 1. Histone H1 : Subtypes and phosphorylation in cell life and death

    Author : Anna Gréen; Ingemar Rundquist; Peter Söderkvist; Rolf Ohlsson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; Cellbiologi;

    Abstract : The genetic information of a human diploid cell is contained within approximately 2 metres of linear DNA. The DNA molecules are compacted and organized in various ways to fit inside the cell nucleus. Various kinds of histones are involved in this compaction. One of these histones, histone H1 is the topic of the present thesis. READ MORE

  4. 2. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression

    Author : Eshagh Dorafshan Esfahani; Yuri B. Schwartz; Jan Larsson; Dale Dorsett; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Trithorax Group proteins; Polycomb Group proteins; PRC1; PRC2; PRE; histone methylation; histone ubiquitylation; Ash1; SET domain; H3K36; H3K27; Drosophila;

    Abstract : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. READ MORE

  5. 3. The release of histone proteins from cells via extracellular vesicles

    Author : Uma Muthukrishnan; Jonathan Gilthorpe; Miles Trupp; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone; extracellular vesicles; exosomes; extracellular histones extracellular DNA; cellular stress; proteomics; ESCRT complex; Lrrn1; mid-hindbrain organizer; ovarian cancer; ascites;

    Abstract : Histones are chromatin-associated proteins localized to the nucleus. However, extracellular histones are present in biofluids from healthy individuals and become elevated under disease conditions, such as neurodegeneration and cancer. READ MORE

  6. 4. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach

    Author : Santhilal Subhash; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Long noncoding RNAs; Chromatin; S-phase; Cell cycle; sperm; Epigenetics; Histone; cancer; oncogene; Tumor suppressor; DNA methylation; Histone modifications; Chromatin remodelers; lncRNAs; lincRNAs;

    Abstract : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. READ MORE

  7. 5. Clinical management of pancreatic cancer aided by histone signatures

    Author : Monika Bauden; Lund Kirurgi; []
    Keywords : Pancreatic cancer; Histone modifications; Tumor size; Biomarkers; Tumor; LC MS MS; Nucleosomics; Histone H1.3;

    Abstract : .... READ MORE