Search for dissertations about: "human glial cells"

Showing result 1 - 5 of 109 swedish dissertations containing the words human glial cells.

  2. 1. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation

    Author : Jinar Rostami; Anna Erlandsson; Martin Ingelsson; Joakim Bergström; Michael Heneka; Uppsala universitet; []
    Keywords : Parkinson’s disease; alpha-synuclein; amyloid-beta; astrocytes; microglia; tunneling nanotubes; antigen presentation; T cells; glial crosstalk; degradation; KYP-2407; Medicinsk vetenskap; Medical Science;

    Abstract : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. READ MORE

  4. 2. Human Embryonic Stem Cells; A novel model system for early human development

    Author : Karin Gertow; Lars Ährlund-Richter; Henrik Semb; Karolinska Institute; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; Human embryonic stem cells; model system; differentiation; xeno-grafting; teratoma; development; karyotype; chromosomal integrity; variant.;

    Abstract : Human embryonic stem cells (HESC) have since their first description in 1998 been recognized as a theoretically endless source of cells capable of differentiation into any somatic cell type. Although great attention has been given to their potential use in cell- based therapy, they are equally important as research tools for studies on early human development, both normal and diseased. READ MORE

  5. 3. Genetic Sex Differences in Early Human Neuronal Development : An Investigation in Embryo Tissue and Embryonic Stem Cells

    Author : Philipp Pottmeier; Elena Jazin; Armin Raznahan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex chromosome; gametolog; x y homolog; male; female; sex differences; sex bias; embryonic stem cells; neurodevelopment; neuronal differentiation; neural stem cells; genetics; neurodevelopmental disorders; Biology with specialization in Evolutionary Organismal Biology; Biologi med inriktning mot evolutionär organismbiologi; Neuroscience; Neurovetenskap; Medicinsk genetik; Medical Genetics;

    Abstract : Sex differences in the human body affect many different organs and tissues, some of them have an effect on the human brain and its development. In the developing nervous system, sex differences can bias the number or functionality of neurons, glial cells or synapses. As a result, neural networks might develop with a sex-specific bias. READ MORE

  6. 4. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells

    Author : Nicolaj Christophersen; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; neurotrophic factors; Parkinson s disease; microarray; dopaminergic; Embryonic stem cells; neural stem cells;

    Abstract : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. READ MORE

  7. 5. Exploring Direct Conversion of Human Glia into Therapeutic Neurons

    Author : Jessica Giacomoni; Utvecklings- och regenerativ neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; glial progenitor cells; neuronal reprogramming; induced neurons; spheroids; brain slice cultures; neurodegenerative disorders;

    Abstract : Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. READ MORE