Search for dissertations about: "human hepatocytes"
Showing result 1 - 5 of 80 swedish dissertations containing the words human hepatocytes.
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1. Proteomics informed investigation of human hepatocytes and liver tissue
Abstract : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. READ MORE
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2. Proteomics-informed analysis of drug disposition in the human liver and small intestine
Abstract : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. READ MORE
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3. Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells
Abstract : Six hundred million people suffering from liver diseases worldwide of which the lethality is two million. Freshly isolated hepatocytes from the liver have been used for transplantation purposes and are extensively used to recapitulate drug metabolism. READ MORE
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4. In vitro toxicity testing using human pluripotent stem cell derivatives
Abstract : .... READ MORE
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5. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo
Abstract : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. READ MORE