Search for dissertations about: "human serum albumin HSA"

Showing result 1 - 5 of 23 swedish dissertations containing the words human serum albumin HSA.

  2. 1. Evasion and Attack: Structural Studies of a Bacterial Albumin-binding Protein and of a Cephalosporin Biosynthetic Enzyme

    Author : Sara Lejon; Janos Hajdu; Karin Valegård; Martin Noble; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; human serum albumin; GA module; albumin-binding; Finegoldia magna; deacetylcephalosporin C acetyltransferase; cephalosporin C; antibiotic; beta-lactam; biosynthesis; Acremonium chrysogenum; X-ray crystallography; Structural biology; Strukturbiologi;

    Abstract : This thesis describes the crystal structures of two proteins in the context of combatting bacterial infections. The GA module is a bacterial albumin-binding domain from a surface protein expressed by pathogenic strains of the human commensal bacterium Finegoldia magna. READ MORE

  4. 2. Development of molecular recognition by rational and combinatorial engineering

    Author : Andreas Jonsson; Stefan Ståhl; Mats Persson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; albumin binding domain; protein engineering; phage display; amyloid beta peptide; TNF; HSA; Molecular biology; Molekylärbiologi;

    Abstract : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. READ MORE

  5. 3. Protein engineering to explore and improve affinity ligands

    Author : Martin Linhult; KTH; []
    Keywords : binding; affinity; human serum albumin HSA ; albumin-binding domain ABD ; affinity chromatography; deamidation; protein A; stabilization; Z-domain; capacity; protein G; cleaning-in-place CIP ; protein engineering; C2 receptor;

    Abstract : In order to produce predictable and robust systems forprotein purification and detection, well characterized, small,folded domains descending from bacterial receptors have beenused. These bacterial receptors, staphylococcal protein A (SPA)and streptococcal protein G (SPG), possess high affinity to IgGand / or HSA. READ MORE

  6. 4. Protein adducts of hexahydrophthalic anhydride- chemical structures and biomarkers

    Author : Monica Kåredal; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; arbetsmiljömedicin; Yrkesmedicin; industrial medicine; Occupational health; nasal lavage; mass spectrometry; biomarker; human serum albumin; hemoglobin; Hexahydrophthalic anhydride; adducts;

    Abstract : Organic acid anhydrides (OAAs) are low molecular weight chemicals used in the industry for manufacturing of plastics such as epoxy resins. Exposure to these chemicals may lead to symptoms from the eyes and the respiratory tract in form of conjunctivitis, rhinitis and asthma. READ MORE

  7. 5. Capacitive Biosensor - A Tool for Ultrasensitive Analysis : Application in Clinical Analysis and Process Monitoring

    Author : Kosin Teeparuksapun; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Capacitive Biosensor; Ultrasensitive Analysis; Clinical Analysis; Bioprocess Monitoring; Human Serum Albumin; HIV-1 p24; Host Cell Proteins; Protein A; Current Pulse;

    Abstract : Increasing demands for highly sensitive, accurate, fast and portable analytical assays have led to the development of new analytical tools. The integration of highly specific biological sensing elements and appropriate transducers has enabled design of even more efficient biosensor devices for the detection of target substances. READ MORE