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Showing result 1 - 5 of 717 swedish dissertations matching the above criteria.

2. 1. Human intestinal alkaline phosphatase : tissue expression and serum levels

   Author : Ulla Domar; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human alkaline phosphatase; intestinal alkaline phosphatase; blood; blood group; lipid; monoclonal antibody; immunohistochemistry; liver; kidney; pancreas; liver disease; inflammatory bowel disease;

   Abstract : Human alkaline phosphatase (ALP) comprises four isozymes, viz liver/bone/ kidney or tissue unspecific (AP), intestinal (LAP), placental (PLAP) and germ cell or PLAP-like alkaline phosphatase, with their main expression in specific tissues as indicated by their names. The isozymes are coded by different genes, but they are closely related, with more than 50% amino acid sequence homologies. READ MORE

4. 2. Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids

   Author : Anne-Li Lind; Torsten Gordh; Masood Kamali-Moghaddam; Jonas Bergquist; Eva Kosek; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chronic pain; neuropathic pain; lumbar radicular pain; amyotrophic lateral sclerosis; radiculopathy; fibromyalgia; pathophysiology; spinal cord stimulation; mechanism of action; disc herniation; cerebrospinal fluid; plasma; biomarker; human; protein; chemokines; cytokines; inflammation; neuroinflammation; mass spectrometry; proximity ligation assay; proximity extension assay; antibody suspension bead array; protein profiling; molecular medicine; personalized medicine; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

   Abstract : Chronic pain affects 20 % of the global population, causes suffering, is difficult to treat, and constitutes a large economic burden for society. So far, the characterization of molecular mechanisms of chronic pain-like behaviors in animal models has not translated into effective treatments. READ MORE

5. 3. Estimating children’s exposure to per- and polyfluoroalkyl substances

   Author : Kerstin Winkens; Ian T. Cousins; Urs Berger; Robin Vestergren; Heather M. Stapleton; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; PFAS; PFAA; fluorinated; fluorotelomer; FTOH; PAP; early life; child; human; exposure; intake; indoor; bedroom; air; dust; serum; Applied Environmental Science; tillämpad miljövetenskap;

   Abstract : Per- and polyfluoroalkyl substances (PFASs) are highly stable, surface active chemicals, which are water- and oil/stain-repellent. Because of their unique properties, PFASs are widely used in consumer products. READ MORE

6. 4. What contributes to human body burdens of halogenated flame retardants? : An experimental approach

   Author : Joo Hui Tay; Cynthia de Wit; Ulla Sellström; Jochen Mueller; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; halogenated flame retardants; air; dust; hand wipes; duplicate diet; serum; human exposure; Applied Environmental Science; tillämpad miljövetenskap;

   Abstract : Flame retardants (FRs) are chemicals added to a broad range of consumer products such as textiles, electrical and electronic equipment, furniture and building material to meet flammability requirements. Most of these chemicals are additives that can continuously leach out from the applied products during usage. READ MORE

7. 5. EMBRYONIC GLIA AND FOREBRAIN NEUROGENESIS; in vitro generation and differentiation of telencephalic neurons

   Author : Charlotta Skogh; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta tubulin III; GFAP; RC2; Neurology; neuropsychology; neurofysiologi; DARPP-32; retinoic acid; serum; EGF; co-culture; cell culture; striatum; LGE; progenitor; precursor; radial glia; region specific; development; CNS; mouse; human; neurophysiology; Neurologi; neuropsykologi;

   Abstract : The current thesis is aimed to increase our understanding of the generation and differentiation of telencephalic neurons, with emphasis on the role of glial cells in these processes. Using in vitro methods we have studied the role of glial cells in neurogenesis, inheritance of genetic regional specification, and influence on differentiation of neurons. READ MORE