Search for dissertations about: "hyperphosphorylation"

Showing result 1 - 5 of 16 swedish dissertations containing the word hyperphosphorylation.

  2. 1. Functional Significance of Multiple Poly(A) Polymerases (PAPs)

    Author : Helena Nordvarg; Claire Moore; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; poly A polymerase; PAP; phosphorylation; isoforms; alternative splicing; kinetic parameters; hyperphosphorylation; regulation; Genetik; Poly A polymeras; PAP; fosforylering; isoformer; alternativ splitsning; kinetiska parametrar; reglering; Clinical genetics; Klinisk genetik; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : 3’ end cleavage and polyadenylation are important steps in the maturation of eukaryotic mRNAs. Poly(A) polymerase (PAP), the enzyme catalysing the addition of adenosine residues, exists in multiple isoforms. In this study the functional significance of multiple poly(A) polymerases have been investigated. READ MORE

  4. 2. Functional proteomics of protein phosphorylation in algal photosynthetic membranes

    Author : Maria Turkina; Peter Strålfors; Göran Samuelsson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein phosphorylation; mass spectrometry; photosynthesis; proteomics; Biochemistry; Biokemi;

    Abstract : Plants, green algae and cyanobacteria perform photosynthetic conversion of sunlight into chemical energy in the permanently changing natural environment. For successful survival and growth photosynthetic organisms have developed complex sensing and signaling acclimation mechanisms. READ MORE

  5. 3. Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease

    Author : Wen-Lin An; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; p70 S6 kinase; tau; protein translation; accumulation; phosphorylation;

    Abstract : One of the important neuropathological features of Alzheimer's disease (AD) is the tau pathology seen as accumulation and hyperphosphorylation of this protein. Evidences showed that tau could be phosphorylated mostly at serine/threonine (S/T) residues by many kinases, including protein kinase B, glycogen synthase kinase (GSK)-3beta, extracellular signal-regulated kinase (ERK1/2), ERK1/2 kinase (MEK1/2), c-Jun Nterminal kinase (JNK), and p38. READ MORE

  6. 4. Design and Synthesis of Inhibitors Targeting BACE-1, an Aspartic Protease Involved in the Pathogenesis of Alzheimer’s Disease

    Author : Veronica Sandgren; Ingemar Kvarnström; Bertil Samuelsson; Thomas Olsson; Linköpings universitet; []
    Keywords : ;

    Abstract : Alzheimer’s disease (AD) is the most common form of dementia, occurring in an estimated 24 million people worldwide. Accumulation of amyloid-b peptides leads to development of plaques in the brain, which eventually stimulates hyperphosphorylation of tau proteins leading to tangles. This is believed to play a crucial role in the pathology of AD. READ MORE

  7. 5. Synthesis of Substituted Alkanethiols Intended for Protein Immobilization : Chelate Associated Photochemistry (CAP)

    Author : Lan Bui; Peter Konradsson; Bo Liedberg; Markus Hederos; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : The first and main part of this thesis is focused on the design and synthesis of photo-activableand metal chelating alkanethiols. Chelate associated photochemistry (CAP) is a novel conceptof combining two well-known protein (ligand) immobilization strategies to obtain a sensorsurface of covalently bound ligand with defined orientation. READ MORE