Search for dissertations about: "ibrutinib"

Showing result 1 - 5 of 15 swedish dissertations containing the word ibrutinib.

  2. 1. Mantle cell lymphoma strategies in primary treatment

    Author : Alexandra Albertsson Lindblad; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mantle cell lymphoma; registry data; Clinical Trial; Phase I; Clinical Trial; Phase II; rituximab; bendamustine; lenalidomid; ibrutinib; ADCC; in vitro model; TP53 mutations; watchful waiting; mantle cell lymphoma; real-world data; lenalidomide; rituximab; bendamustin; ibrutinib; ADCC; TP53 mutation; CDKN2A; NGS; MIPI; Watchful waiting;

    Abstract : Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. READ MORE

  4. 2. Immune cells in chronic lymphocytic leukemia and Hodgkin lymphoma in relation to tumor burden and treatment

    Author : Tom Adriaan Mulder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : B-cell malignancies are a heterogeneous group of cancers that originate from lymphoidlineage cells that are responsible for humoral immunity. When B-cell development goes wrong, chronic lymphocytic leukemia (CLL) and classical Hodgkin lymphoma (cHL), among other malignancies, may arise. Recent advances in the treatment of these diseases, e.g. READ MORE

  5. 3. Targeted therapy in chronic lymphocytic leukemia

    Author : Maria Winqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature B lymphocytes in blood, bone marrow and lymphoid tissues. Historically, patients with TP53 aberration and with refractoriness to chemoimmunotherapy had a dismal prognosis. READ MORE

  6. 4. Estrogen regulation of non-Hodgkin lymphomas and its underlying mechanisms

    Author : Dan Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Most non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL), show a higher male to female incidence ratio. The reason for this is not clear, but epidemiological and experimental studies have suggested a role for estrogens in NHL acting via estrogen receptor β (ERβ). READ MORE

  7. 5. Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy

    Author : Qing Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic leukemia (CLL). However, a sub-group of patients develops resistance to ibrutinib therapy. READ MORE