Search for dissertations about: "imipramine"

Showing result 1 - 5 of 7 swedish dissertations containing the word imipramine.

  2. 1. Clinical studies of panic disorder

    Author : Sven Andersch; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Panic disorder; alprazolam; imipramine; agoraphobia; social phobia; psychiatric comorbidity; MAO; long-term course; daily life functioning.;

    Abstract : Aims: To study efficacy and safety of alprazolam, imipramine, and placebo in treatment of panic disorder, to investigate comorbidity with social phobia, to determine platelet monoamine oxidase (MAO), and to follow the long-term course in a cohort of patients with panic disorder.Subjects and Methods: A double-blind comparison of alprazolam, imipramine, and placebo was performed in 123 Scandinavian outpatients with panic disorder according to DSM-III. READ MORE

  4. 2. Serotonergic and steroidal influences on impulsive behaviour in rats

    Author : John L. Evenden; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; impulsivity; serotonin; 8-OH-DPAT; DOI; steroid; testosterone; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Impulsiveness is a trait contributing to the personality of all human beings to a greater and lesser extent. In a pathological form it can lead to impulsive behaviour which is an important component of many psychiatric and neurological disorders. READ MORE

  5. 3. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

    Author : Ann Tronde; Gerrit Borchard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. READ MORE

  6. 4. In vitro studies on the potential immunosuppressive and antitumor effects of antidepressants : induction of apoptosis in human T-cells and a myeloid leukemia cell line

    Author : Zhenlei Xia; Tom Cotter; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Abstract : Antidepressants are widely used in treating depressive disorders. It has been demonstrated that several components of the immune system may be activated in the acute clinical stage of major depression and that such activation may play a role in the onset of depressive symptoms. READ MORE

  7. 5. Therapy-resistant enuresis : In search of new therapies and prognostic markers

    Author : Elisabet Lundmark; Tryggve Nevéus; Arne Stenberg; Sievert Lindström; Uppsala universitet; []
    Keywords : Nocturnal enuresis; Reboxetine; Antidepressants; Desmopressin; Voiding chart; Pediatrik; Pediatrics;

    Abstract : A large minority of children with enuresis do not respond to treatment with either desmopressin or the enuresis alarm. Anticholinergics have not proven as successful as expected. The fourth evidence-based treatment of enuresis, the tricyclic antidepressant imipramine, is cardiotoxic when overdosed, which has led to diminished use. READ MORE