Search for dissertations about: "immunomodulatory antimicrobial peptides"

Showing result 1 - 5 of 11 swedish dissertations containing the words immunomodulatory antimicrobial peptides.

2. 1. Novel Endogenous Antimicrobial Peptides

   Author : Emma Nordahl; Lund Dermatologi och venereologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; D5; HK; C3a; HMWK; complement; heparin-binding; antibacterial; Antimicrbial peptide; AMP;

   Abstract : Antimicrobial peptides serve as a first line of defence against invading microorganisms and are an essential part of our fast innate immune system. They are ancient molecules found in all classes of life. Antimicrobial peptides rapidly kill a broad spectrum of microbes and are immunomodulatory, i.e. READ MORE

4. 2. Functional dualism of antimicrobial host defence peptides

   Author : Åse Björstad; Göteborgs universitet; []
   Keywords : antimicrobial; apoptosis; cathelicidin; host defence peptide; interleukin 8; LL-37; permeabilisation;

   Abstract : Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the bifunctional Helicobacter pylori peptide, Hp(2-20), were synthesised and inhibition zone assays and chemiluminescence systems were employed for determination of direct antimicrobial action and superoxide release (immunomodulatory) from human neutrophils, respectively. READ MORE

5. 3. Actions of Antimicrobial Peptides and Bacterial Components in Inflammation

   Author : Thorgerdur Sigurdardottir; Anestesiologi och intensivvård; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; LL-37; M1 protein; S. pyogenes; Toll-like receptors; phenylephrine; nitr1c oxide; antimicrobial peptides;

   Abstract : Antimicrobial peptides are evolutionally ancient parts of the innate immune system and their primary role is to protect us from infections. The human cathelicidin-derived antimicrobial peptide, LL-37, not only possesses broad spectrum antimicrobial activities but is also able to bind and neutralize bacterial lipopolysaccharide (LPS), an important trigger of the widespread inflammatory response contributing to septic shock. READ MORE

6. 4. Targeting bacterial infections by using immunomodulatory host defence peptides and proteins

   Author : Martina Kalle; Lund Dermatologi och venereologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host dfence peptides; Sepsis; Immunomodulation; Heparin cofactor II;

   Abstract : Bacterial infections and sepsis are amongst the leading causes of death worldwide. Sepsis is caused by an uncontrolled systemic host response towards an invading pathogen. Due to the engagement of various systems including cellmediated responses, the coagulation and complement cascades, treatment of sepsis remains challenging. READ MORE

7. 5. Expression and regulation of antimicrobial peptides in mucosal immunity

   Author : Andreas Cederlund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Antimicrobial polypeptides (AMPs) are effector molecules of the innate immune defense. AMPs are mainly expressed in epithelial cells and immune cells, providing the first line of defense to infection as direct antimicrobials. In addition, many AMPs display immunomodulatory functions in both the adaptive and innate immune system. READ MORE