Search for dissertations about: "in situ hybridisation"

Showing result 21 - 25 of 63 swedish dissertations containing the words in situ hybridisation.

2. 21. Molecular aspects of WNT/Frizzled signalling in brain angiogenesis

   Author : Belma Hot; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The family of WNT lipoglycoproteins consists of 19 secreted proteins that are important for multiple cellular processes including cell proliferation, migration and fate. WNTs induce signalling cascades by binding the seven transmembrane receptors named Frizzleds (FZDs) classified as G protein-coupled receptors (GPCRs). READ MORE

4. 22. SODIUM/IODIDE SYMPORTER-NIS Abundant and Important in Gastric Mucosa

   Author : Malin Josefsson; Neurogastroenterologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ussing chamber; MNNG; gastric iodide secretion; ouabain; gastric cancer; sodium perchlorate; gastric NIS; bile duct cancer; Sodium iodide symporter;

   Abstract : ABSTRACT Background: Iodine is essential for development and growth as a constituent in thyroid hormones. Biological mechanisms for iodide uptake and concentration are very important, espe-cially as iodine is a relatively scarce element. READ MORE

5. 23. Brain galanin sytems and their role in depression-like behaviour

   Author : Eugenia Kuteeva; Karolinska Institutet; Karolinska Institutet; []
   Keywords : 5-HT1A receptor; depression-like behaviour; forced swim test; galanin; galanin-overexpressing; galanin receptor; noradrenaline; serotonin; transgenic mouse;

   Abstract : The aim of the present thesis was to investigate the role of the neuropeptide galanin and galanin receptor subtypes in behavioural functions with a particular focus on depression-like behaviour. In agreement with its wide distribution in the central nervous system, galanin has been implicated in various functions, including regulation of reproduction, endocrine functions, antinociception, attention, learning and memory as well as regulation of mood. READ MORE

6. 24. Spinal motoneurones and the bulbospinal serotonininergic system in aged rats with behavioral deficits

   Author : Hans Johnson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : aging; behavior; immunohistochemistry; in situ hybridisation; motoneuron; CGRP; axotorny; GAP-43; neurotrophin receptors; degeneration; axon dystrophy; 5HT TRH; SP; 5HLkA; AADC; serotonintransporter protein; fluoxetine; L-5-HTP;

   Abstract : The expression of neuropeptides, growth-related proteins and neurotrophin receptors were studied in motoneurons of young adult rats and in aged rats with symptoms of neuromuscular incapacities. Also studied were aging-related changes in the descending serotoninergic (5HT) bulbospinal system which constitutes a major afferent pathway to spinal motoneurons. READ MORE

7. 25. Metabolomic features and viral infections in paediatric inflammatory bowel disease

   Author : Niklas Nyström; Jonas Halfvarson; Kjell Alving; Yigael Finkel; Ignacio Catalan Serra; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory bowel disease; IBD; Crohn s disease; ulcerative colitis; pediatric; metabolomics; lipidomics; enterovirus; coxsackievirus; Pediatrik; Pediatrics; Internal Medicine; Internmedicin;

   Abstract : Background: Up to 25% of patients with inflammatory bowel disease have a paediatric onset (PIBD). The pathophysiological processes underlying PIBD are complex and largely unknown.  Aims: To investigate a hypothesized role for human enterovirus B (HEV-B) in Crohn’s disease (CD) (I). READ MORE