Search for dissertations about: "in vitro and in vivo"

Showing result 1 - 5 of 1642 swedish dissertations containing the words in vitro and in vivo.

  1. 1. Assessment of human swallowing using in-vivo and in-vitro approaches

    University dissertation from Chalmers University of Technology

    Author : Waqas Qazi; Chalmers tekniska högskola.; Chalmers University of Technology.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; In-vivo analysis; extensional rheology; Ultrasound viscometry; in-vitro manometery; dysphagia; Bolus Rheology; In-vitro simulations; microstructure analysis;

    Abstract : Texture modification is the most vital strategy to manage dysphagia: a condition in which food and beverages are difficult to swallow. Typically thickeners in the form of starch or gums are added to the food to increase the viscosity and thereby reduce the speed of bolus flow. READ MORE

  2. 2. Development of Methods for Assessing Unbound Drug Exposure in the Brain In vivo, in vitro and in silico

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Fridén; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; PHARMACY Other pharmacy; FARMACI Övrig farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE

  3. 3. The Role of Chlamydia pneumoniae-induced Platelet Activation in Cardiovascular Disease In vitro and In vivo studies

    University dissertation from Institutionen för medicin och vård

    Author : Hanna Kälvegren; Linköpings universitet.; Linköpings universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia pneumoniae; Platelet; atherosclerosis; Infection; LDL-oxidation; Percutaneous coronary intervention; Cardiovascular disease; Serotonin; Reactive oxygen species production; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi;

    Abstract : The common risk factors for atherosclerosis, such as obesity, high cholesterol levels, sedentary lifestyle, diabetes and high alcohol intake, only explain approximately 50% of cardiovascular disease events. It is thereby important to identify new mechanisms that can stimulate the process of atherosclerosis. READ MORE

  4. 4. Regulation of Renal Hyaluronan in Water Handling Studies in vivo and in vitro

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Stridh; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; water balance; fluid handling; diabetes; nephropathy; ACE fetopathy; reabsorption; hyaluronic acid; glycosaminoglycan; GAG; extracellular matrix; mTOR; rapamycin; streptozotocin;

    Abstract : Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-attracting properties. It is the dominating ECM component in the renal medullary interstitium, where the amount changes in relation to hydration status: it increases during hydration and decreases during dehydration. READ MORE

  5. 5. Regulation of Ovarian Aromatase: Studies by Aromatase Assays in vitro and in vivo

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Dmitrijus Kirilovas; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; aromatase; human; granulosa cells; 11C-vorozole; active site; allosteric configuration; in vitro; in vivo; PET; androgens; rat; estrous cycle.; Obstetrik och kvinnosjukdomar; MEDICINE Surgery Obstetrics and women s diseases; MEDICIN Kirurgi Obstetrik och kvinnosjukdomar; Obstetrics and Gynaecology; obstetrik och gynekologi;

    Abstract : An in vitro method was developed for measuring aromatase, based on binding of competitive aromatase inhibitor [11C]vorozole to the active site of the enzyme. [11C]Vorozole displayed high, specific binding in vitro to human placenta and human granulosa cells (GC), both fresh and frozen/thawed cells, provided correct procedures were used. READ MORE