Search for dissertations about: "in vitro developmental toxicity"

Showing result 1 - 5 of 14 swedish dissertations containing the words in vitro developmental toxicity.

  2. 1. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    Author : Måns Jergil; Lennart Dencker; Aldert Piersma; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

  4. 2. In vitro developmental neurotoxicity of acrylamide

    Author : Kristina Attoff; Anna Forsby; Ann-Kristin Östlund Farrants; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The number of children with neurodevelopmental disorders is increasing worldwide which makes it a public concern. Exposure to environmental chemicals has been reported as a source of developmental neurotoxicity. READ MORE

  5. 3. Bioactivation and binding of polycyclic aromatic hydrocarbons in blood vessel endothelia

    Author : Lizette Granberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Polycyclic aromatic hydrocarbon; PAH; endothelial cells; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Ecotoxicology; ekotoxikologi;

    Abstract : Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants formed by incomplete combustion of organic materials such as fossil fuels and wood. Experimental and epidemiological studies indicate that PAHs may be involved in the development of cardiovascular disease. READ MORE

  6. 4. Transcriptomics and Proteomics Applied to Developmental Toxicology

    Author : Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
    Keywords : Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE

  7. 5. Developmental Neurotoxicity Testing Using In vitro Approaches

    Author : Helena Högberg; Anna Price; Barbara Cannon; Kevin Crofton; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologi; Toxicology;

    Abstract : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. READ MORE