Search for dissertations about: "in vitro release"

Showing result 1 - 5 of 241 swedish dissertations containing the words in vitro release.

  1. 1. Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective

    University dissertation from Stockholm : KTH

    Author : Klara Midander; KTH.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ferro-chromium alloy; metal particles; bioaccessibility; chemical speciation; dermal contact; surface oxide; in-vitro testing; chemical speciation; cu; copper; comet assay; intracellular; ultrafine; in vitro; A549; cytotoxicity; DNA damage; nanoparticles; particle characterization; artificial sweat; nickel release; nickel powder particles; particle loadings; release kinetics; surface area; copper release; powder particles; synthetic body fluids; simulation of interstitial lung conditions; skin contact; metal release; stainless steel; particles; test method; NATURAL SCIENCES Chemistry Physical chemistry Surface and colloid chemistry; NATURVETENSKAP Kemi Fysikalisk kemi Yt- och kolloidkemi; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi; NATURAL SCIENCES Chemistry Analytical chemistry Spectroscopy; NATURVETENSKAP Kemi Analytisk kemi Spektroskopi;

    Abstract : Do metal particles (including particles of pure metals, alloys, metal oxides and compounds) pose a hazard or risk to human health? In the light of this question, this thesis summarizes results from research conducted on metal particles, and describes the elaboration and implementation of an in vitro test methodology to study metal release from particles through corrosion and dissolution processes in synthetic biological media relevant for human exposure through inhalation/ingestion and dermal contact.Bioaccessible metals are defined as the pool of released metals from particles that potentially could be made available for absorption by humans or other organisms. READ MORE

  2. 2. The Role of Chlamydia pneumoniae-induced Platelet Activation in Cardiovascular Disease In vitro and In vivo studies

    University dissertation from Institutionen för medicin och vård

    Author : Hanna Kälvegren; Linköpings universitet.; Linköpings universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia pneumoniae; Platelet; atherosclerosis; Infection; LDL-oxidation; Percutaneous coronary intervention; Cardiovascular disease; Serotonin; Reactive oxygen species production; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi;

    Abstract : The common risk factors for atherosclerosis, such as obesity, high cholesterol levels, sedentary lifestyle, diabetes and high alcohol intake, only explain approximately 50% of cardiovascular disease events. It is thereby important to identify new mechanisms that can stimulate the process of atherosclerosis. READ MORE

  3. 3. In Vitro – In Vivo Correlation of Injectable Lipid Formulations

    University dissertation from Hospital Pharmacy, University Hospital, Malmö, Sweden and Department of Food Technology, Engineering and Nutrition, Lund University, Sweden

    Author : Lars Söderberg; Lunds universitet.; Lund University.; [2008]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; erythrocyte; EC 50; human plasma; lipid injectable formulation; IVIVC; fatty acid; in vitro release; Peripheral nerve block; neurolytic; structure-activity;

    Abstract : In order to develop new pharmaceuticals, to optimize pharmacotherapy and secure patient safety, documentation of the properties of pharmaceutical formulations is a most important process. A significant practical problem associated with pre-clinical evaluation of lipophilic substances with pharmacological properties is their low aqueous solubility. READ MORE

  4. 4. Regulation of Ovarian Aromatase: Studies by Aromatase Assays in vitro and in vivo

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Dmitrijus Kirilovas; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; aromatase; human; granulosa cells; 11C-vorozole; active site; allosteric configuration; in vitro; in vivo; PET; androgens; rat; estrous cycle.; Obstetrik och kvinnosjukdomar; MEDICINE Surgery Obstetrics and women s diseases; MEDICIN Kirurgi Obstetrik och kvinnosjukdomar; Obstetrics and Gynaecology; obstetrik och gynekologi;

    Abstract : An in vitro method was developed for measuring aromatase, based on binding of competitive aromatase inhibitor [11C]vorozole to the active site of the enzyme. [11C]Vorozole displayed high, specific binding in vitro to human placenta and human granulosa cells (GC), both fresh and frozen/thawed cells, provided correct procedures were used. READ MORE

  5. 5. Poly(Lactide-co-Glycolide) in Controlled-Release Pharmaceuticals - Release Mechanisms

    University dissertation from Department of Chemical Engineering, Lund University

    Author : Susanne Fredenberg; Lunds universitet.; Lund University.; [2011]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Poly lactide-co-glycolide ; PLGA; Release mechanism; Diffusion; Controlled Release; Degradation; Protein;

    Abstract : Controlled-release formulations reduce the frequency of injections and better maintain plasma concentrations within the therapeutic window. Poly(D,L-lactide-co-glycolide) (PLG) is currently the most frequently used biodegradable polymer for this application. READ MORE