Search for dissertations about: "in-vitro testing"

Showing result 1 - 5 of 164 swedish dissertations containing the words in-vitro testing.

2. 1. Evaluation of a Miniaturized Rotating Disk Apparatus for In Vitro Dissolution Rate Measurements in Aqueous Media : Correlation of In Vitro Dissolution Rate with Apparent Solubility

   Author : Anita M. Persson; Curt Pettersson; Anders Sokolowski; Anders Karlsson; Alex Avdeef; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; analytical methods; HPLC high-performance liquid chromatography ; miniaturization; in vitro dissolution rate; apparent solubility; physicochemical properties; dissolution media; correlation study; chemometrics; Pharmaceutical chemistry; Farmaceutisk kemi; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Abstract : The general aim of this thesis was to evaluate a newly designed and constructed miniaturized rotating disk apparatus for in vitro dissolution rate measurements of different drug substances from all of the classes in the Biopharmaceutical Classification System (BCS). The new equipment is based on a low volume flow-through cell of Plexiglas, a gold plated magnetic bar and a special designed press. READ MORE

4. 2. Exploring Cancer Drugs In Vitro and In Vivo : With Special Reference to Chemosensitivity Testing and Early Clinical Development

   Author : Anne von Heideman; Peter Nygren; Bengt Tholander; Rolf Larsson; Seija Grénman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic drug; in vitro assay; drug development; phase I clinical trial; Oncology; Onkologi; Oncology; Onkologi;

   Abstract : The aims of this thesis were to investigate the utility of in vitro drug sensitivity testing to optimize the use of cancer chemotherapy and to assess the properties of a new cancer drug in a phase I clinical trial. Tumour cells from patients were analysed with the short-term Fluorometric Microculture Cytotoxicity Assay (FMCA). READ MORE

5. 3. Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective

   Author : Klara Midander; Inger Odnevall Wallinder; Sannakaisa Virtanen; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ferro-chromium alloy; metal particles; bioaccessibility; chemical speciation; dermal contact; surface oxide; in-vitro testing; chemical speciation; cu; copper; comet assay; intracellular; ultrafine; in vitro; A549; cytotoxicity; DNA damage; nanoparticles; particle characterization; artificial sweat; nickel release; nickel powder particles; particle loadings; release kinetics; surface area; copper release; powder particles; synthetic body fluids; simulation of interstitial lung conditions; skin contact; metal release; stainless steel; particles; test method; Surface and colloid chemistry; Yt- och kolloidkemi; Analytical chemistry; Analytisk kemi; Spectroscopy; Spektroskopi;

   Abstract : Do metal particles (including particles of pure metals, alloys, metal oxides and compounds) pose a hazard or risk to human health? In the light of this question, this thesis summarizes results from research conducted on metal particles, and describes the elaboration and implementation of an in vitro test methodology to study metal release from particles through corrosion and dissolution processes in synthetic biological media relevant for human exposure through inhalation/ingestion and dermal contact. Bioaccessible metals are defined as the pool of released metals from particles that potentially could be made available for absorption by humans or other organisms. READ MORE

6. 4. Developmental Neurotoxicity Testing Using In vitro Approaches

   Author : Helena Högberg; Anna Price; Barbara Cannon; Kevin Crofton; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologi; Toxicology;

   Abstract : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. READ MORE

7. 5. GARD : An in vitro platform for toxicological assay development

   Author : Robin Gradin; Institutionen för immunteknologi; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; In vitro assay; predictive modelling; skin sensitization; Toxicology;

   Abstract : Life in modern society is intricately intertwined with the results of continuous technological advances. Thishas given rise to daily routines where people are frequently exposed to a wide variety of chemicals. READ MORE