Search for dissertations about: "induced cardiotoxicity"

Found 5 swedish dissertations containing the words induced cardiotoxicity.

2. 1. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study

   Author : Magdalena Cwikiel; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; cell culture.; scanning and transmission electron microscopy; endothelium; lipid peroxidation; free radical; fibrinogen; 5-fluorouracil; blood and plasma viscosity; cardiotoxicity; cancerology; Cytologi; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Abstract : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). READ MORE

4. 2. Assessment of Drug-Induced Cardiotoxicity during Rat Embryo Development

   Author : Mats Nilsson; William S. Webster; Nigel A. Brown; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The potassium ion channel (hERG/IKr) is important for normal heart function and drug-induced blockade of the channel in adult humans can lead to irregular heart rhythms (arrhythmia).  The ion channel is also essential for early cardiac function in the embryo and therapeutic drugs which block this channel have been shown to cause birth defects in animal studies. READ MORE

5. 3. p38 MAPK Signalling in Endothelial Apoptosis

   Author : Simone Grethe; Malmö Experimentell patologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; PP2A; Bad; Bcl-xL; doxorubicin; TNF; p38 MAPK; Apoptosis; endothelial cells;

   Abstract : Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. READ MORE

6. 4. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study

   Author : Sara Kinhult; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; endothelin; onkologi; Cytologi; cancer; von Willebrand factor; thrombomodulin; lipoperoxidation; probucol; low-molecular weight heparin; scanning electron microscopy; 5-fluorouracil; endothelium;

   Abstract : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. READ MORE

7. 5. Studies of side effects related to adjuvant breast cancer regimens with focus on chemotherapy

   Author : Andri Papakonstantinou; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Radiotherapy, endocrine therapy, chemotherapy and targeted therapy adjunct to surgery have a critical role in the management of early breast cancer for outcome improvement. Anthracycline containing chemotherapy reduces 10-year incidence of breast cancer mortality by an absolute 6. READ MORE