Search for dissertations about: "induced pluripotent stem cells"

Showing result 1 - 5 of 81 swedish dissertations containing the words induced pluripotent stem cells.

2. 1. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

   Author : Måns Jergil; Lennart Dencker; Aldert Piersma; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; Toxicology; Toxikologi; Toxicology; Toxikologi;

   Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

4. 2. Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts

   Author : Karthikeyan Devaraju; Lund Neurologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adult neurogenesis; stroke; neural stem cells; Lnk; ependymal cells; FoxJ1; cortical reprogramming;

   Abstract : Stroke is a major cause of death and disability around the world. Stroke leads to loss of neurons and also other cells in the brain due to lack of blood supply. Currently no therapies are available to treat stroke-related disability. It has been shown that stroke leads to increased neurogenesis, birth of new neurons, within the brain. READ MORE

5. 3. Manipulating neural stem cells

   Author : Malin Eriksson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The stem cell field is a fairly young but fast growing scientific field. Our understanding of stem cells has changed tremendously over the last couple of decades. This in mainly due to the development of new techniques that has enabled us to study stem cells from a completely new perspective. READ MORE

6. 4. Human induced pluripotent stem cells in regenerative medicine

   Author : Elias Uhlin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Human induced pluripotent (iPS) cells offer a theoretically inexhaustible cell source for the derivation of any cell type and are a promising tool in regenerative medicine. Cells can be derived from the recipients own tissue or from pre-selected HLA-matched donors. READ MORE

7. 5. Device Bonding and Antibody Binding: Developments for On-Chip Differentiation of Induced Pluripotent Stem Cells into Hepatocytes

   Author : Philip Dalsbecker; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Microfluidics; liver-on-a-chip; organ-on-chip; PDMS; oxygen plasma; immunofluorescence; fluorescence microscopy; hepatocytes; iPSC; induced pluripotent stem cells; differentiation; on-chip differentiation; definitive endoderm;

   Abstract : Abstract This thesis describes the bonding optimization of a liver-on-a-chip microfluidic device for evaluation of cultured induced pluripotent stem cell (iPSC)-derived definitive endoderm (DE) cells during their targeted differentiation into mature hepatocytes. Furthermore, it describes the optimization of a number of antibody assays for use during said differentiation, for the purpose of studying the cellular phenotype. READ MORE