Search for dissertations about: "insulin and glucagon secretion"
Showing result 6 - 10 of 71 swedish dissertations containing the words insulin and glucagon secretion.
-
6. Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans
Abstract : Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon secretion, independent of membrane potential, from pancreatic α-cells, via modulation of endoplasmic reticulum Ca2+ handling. READ MORE
-
7. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
Abstract : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). READ MORE
-
8. Origin, release and functional significance of the novel gastric hormone ghrelin
Abstract : The novel gastric hormone ghrelin was discovered by virtue of its ability to release growth hormone (GH) via interaction with the so-called GH-secretagogue receptor (GHS-R). Earlier only synthetic agents were known to bind with the GHS-R, hence, ghrelin is the first identified endogenous ligand. READ MORE
-
9. Islet hormonal hypersecretion and metformin’s effect on islet hormonal secretion studied in vitro and in vivo
Abstract : Childhood obesity has surged globally. Elevated levels of free fatty acids contribute to hyperinsulinemia, hyperproinsulinemia, and hyperglucagonemia connected with both obesity and type 2 diabetes mellitus (T2DM). Metformin has beneficial effects on islets by influencing metabolism and reducing stress-induced cell death. READ MORE
-
10. Peripheral immunity in patients with autoimmune endocrine diseases and the influence of physiological adaptions during pregnancy
Abstract : Type 1 diabetes (T1D), Hashimoto’s thyroiditis (HT), Graves’ disease (GD), and autoimmune Addison’s disease (AD) appear to share immunogenetic mechanisms. This idea is not novel, as “autoimmune tautology” is an established concept. READ MORE