Search for dissertations about: "insulin maturation"

Showing result 1 - 5 of 34 swedish dissertations containing the words insulin maturation.

  2. 1. Regulation of the exocrine pancreas in growing pigs, with special emphasis on entero-pancreatic reflexes

    Author : Lena Evilevitch; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; kidney bean lectin; Animal physiology; Djurfysiologi; duodenum; entero-pancreatic reflex; insulin; lipas; amylas; trypsin; weaning; development; maturation; inhibition; CCK-receptors; Exocrine pancreas; CCK; pig;

    Abstract : The regulation of the exocrine pancreas has been under thorough investigation for many decades. In rats, cholecystokinin (CCK) is considered to be the major gut hormone stimulating the pancreas to releasing the digestive enzymes. READ MORE

  4. 2. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes

    Author : Yuedan Zhou; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TCF7L2; rs7903146; Type 2 diabetes; β cell function; β cell survival; insulin secretion; proinsulin synthesis; proinsulin-to-insulin conversion; insulin maturation; open chromain; exon skipping; p53; TP53INP1; ISL1; MAFA; NEUROD1; PDX1; NKX6.1; PCSK1; PCSK2; SLC30A8; GWAS.;

    Abstract : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. READ MORE

  5. 3. The Best Leading Role for Maintaining Normal β-cell Function Goes to MafA and Voltage-gated Calcium Channel Subunit γ4

    Author : Cheng Luan; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; insulin secretion; pancreatic islet; MafA; CaVγ4; CaV channels; β-cell function; dedifferentiation; transcription factor; patch clamp; Ca2 signaling; cholinergic nicotinic receptor; ChrnB4; GDF11; aging; islet inflammation; maturation;

    Abstract : .... READ MORE

  6. 4. Growth hormone and somatolactin function during sexual maturation of female Atlantic salmon

    Author : Susana Benedet Perea; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Growth hormone; somatolactin; insulin-like growth factor I; GH; SL; IGFI; GHR; SLR; IGFIR; ovary maturation; reproduction; Atlantic salmon; spawning; pituitary;

    Abstract : Background and aims: The growth hormone-insulin-like growth factor I (GH-IGF-I) system is known to act during sexual maturation of female salmonids, but the specific roles are not known. Somatolactin (SL) is a pituitary hormone closely related to GH and is only found in fish. In some species, including salmonids, there are two forms, SLa and SLß. READ MORE

  7. 5. Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function

    Author : Magdalena Mazur; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreas development; beta cells; insulin; MafA; MafB; Mitf; diabetes;

    Abstract : Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. READ MORE