Search for dissertations about: "interleukin-1 alpha"

Showing result 1 - 5 of 23 swedish dissertations containing the words interleukin-1 alpha.

  2. 1. Blocking interleukin-1 signalling in the brain-structural and functional outcomes

    Author : Stefan Spulber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist with the GFAP promoter (Tg hsIL-1ra). READ MORE

  4. 2. Interactions between Malignant Keratinocytes and Fibroblasts : Studies in Head and Neck Squamous Cell Carcinoma

    Author : Malin Hakelius; Daniel Nowinski; Bengt Gerdin; Kristofer Rubin; Avni Abdiu; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coculture; extracellular matrix; interleukin-1 alpha; tumor stroma; differential gene regulation; innate response; Plastic Surgery; Plastikkirurgi;

    Abstract : Carcinoma growth requires a supportive tumor stroma. The concept of reciprocal interactions between tumor and stromal cells has become widely acknowledged and the connective tissue activation seen in the malignant process has been likened to that of a healing wound. READ MORE

  5. 3. Cytokines in the nervous system with emphasis on interleukin-1 receptor-mediated activity

    Author : Mircea Oprica; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Interleukin-1 (IL-1) is one of the most important pro-inflammatory cytokines and plays a pivotal role in the neuroinflammation associated with certain forms of neurodegeneration, such as epilepsy, cerebral ischemia, trauma, and Alzheimer's disease (AD). Also, it was suggested that IL-1 is involved in physiological processes, namely modulation of sleep, glucose and lipid metabolism, and neuroendocrine regulation, as well as modulation of learning and memory. READ MORE

  6. 4. Region-specific expression of the interleukin-1 system in rat brain following endotoxin challenge and excitotoxic neurodegeneration

    Author : Charlotta Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Traditionally, up-regulation and secretion of cytokines are associated with peripheral immune and inflammatory responses. There is now evidence that cytokines also exert various actions in the central nervous system (CNS). READ MORE

  7. 5. Testicular interleukin-1 alpha: Isolation, purification and and identification of a constitutively produced and secreted cytokine by the intact adult rat testis

    Author : Katarina Gustafsson; Karolinska Institutet; []
    Keywords : Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : .... READ MORE