Search for dissertations about: "internal validation"
Showing result 1 - 5 of 114 swedish dissertations containing the words internal validation.
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1. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials
Abstract : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. READ MORE
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2. Development and Validation of HPLC Methods for Analytical and Preparative Purposes
Abstract : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. READ MORE
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3. Validation and Application of CFD to Safety-Related Phenomena in Lead-Cooled Fast Reactors
Abstract : Carbon-free nuclear power production can help to relieve the increasing energy demand in the world. New generation reactors with improved safety, sustainability, reliability, economy and security are being developed. Lead-cooled fast reactor (LFR) is one of them. READ MORE
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4. Epidemiological Aspects of Asthma in Primary Care : Special Reference to Prevalence, Clinical Detection and Validation
Abstract : Objectives. To describe the prevalence of asthma in a mid-Swedish region and measure the detection rate of asthma in primary care. To compare clinical outcomes for adolescents with asthma in primary care or in paediatric care and to perform a clinical validation in children with airway, nose and skin symptoms. Material and methods. READ MORE
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5. Transient vibrations from dry clutch operation in heavy-duty truck powertrains : Modelling, simulation and validation
Abstract : For internal combustion engines used in heavy-duty vehicles, increased engine efficiency and consequently reduced CO2 emissions can be obtained if the engine speed can be kept within an optimal speed range. This requires swift and frequent gear shifts where the dry friction clutch is utilized. READ MORE