Search for dissertations about: "intracellular transport"
Showing result 1 - 5 of 199 swedish dissertations containing the words intracellular transport.
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1. The Hepatobiliary Transport of Rosuvastatin In Vivo
Abstract : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. READ MORE
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2. Intracellular unbound drug concentrations : Methodology and application for understanding cellular drug exposure
Abstract : Most known drug targets and metabolizing enzymes are located inside cells. Interactions with these proteins are determined by intracellular unbound drug concentrations. Assessing intracellular drug exposure is technically challenging, but essential for predicting pharmacokinetic, pharmacological, and toxicological profiles of new drugs. READ MORE
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3. Intracellular protein transport in plants : targeting, sorting and processing
Abstract : .... READ MORE
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4. Characterization of parameters influencing intracellular bioavailability and prediction of intracellular drug exposure
Abstract : This thesis work investigates factors influencing intracellular drug disposition. An experimental method for measurement of intracellular bioavailability (Fic), was used throughout. Fic is defined as the ratio between the unbound drug concentration inside the cell and the compound concentration in the cell exterior. READ MORE
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5. Membrane-remodeling by SNX18 in endosomal transport and autophagy
Abstract : The intracellular space of eukaryotic cells is subdivided into functionally distinct membrane-enclosed organelles. Regulation of these intracellular membranes requires an intricate network of specialized lipids and proteins that maintain organellar integrity and mediate transport between organelles. READ MORE