Search for dissertations about: "intranasal immunization"

Showing result 1 - 5 of 19 swedish dissertations containing the words intranasal immunization.

  2. 1. PROTEIN VACCINE AGAINST NEONATAL GROUP B STREPTOCOCCAL INFECTION Immunization experiments in animals and a serological study in humans

    Author : Charlotte U Larsson; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bakteriologi; mycology; bacteriology; Microbiology; virologi; mykologi; neonatal infection; human antibody; intranasal; vaccine; cholera toxin B subunit; Rib; α; Group B streptococcus; surface protein; Mikrobiologi; virology;

    Abstract : Infection with group B streptococcus (GBS), an encapsulated bacterium, is an important cause of neonatal morbidity and mortality. Capsular polysaccharides and cell surface proteins of GBS are candidate antigens for development of a human GBS vaccine. Proteins have many advantages as vaccine antigens. READ MORE

  4. 2. Studies in DNA immunization

    Author : Cecilia Svanholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chlamydia pneumoniae; DNA vaccine; GM-CSF; HIV-1; hsp60; Nef; Rev; Tat; signal sequence;

    Abstract : This thesis describes investigations and developments of DNA immunization techniques, which were applied in the study of two different pathogens; HIV-1 and Chlamydia pneumoniae. DNA vaccines, i.e. naked plasmid DNA encoding an antigen, represent a novel strategy for generating protective immunity against several infectious diseases. READ MORE

  5. 3. Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection

    Author : Valentina Bernasconi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucosal vaccination; Influenza A virus; CTA1-DD; Nanoparticle; Targeted adjuvant; Nasal immunization; Oral immunization; Neonatal vaccine; Universal vaccine;

    Abstract : Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. READ MORE

  6. 4. The development of a new combined adjuvant vector for mucosal immunization CTA1-DD/ISCOM

    Author : Anja Helgeby; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CTA1-DD; ISCOM; adjuvants; enzyme; vaccine; B cell; Dendritic cell; T cells;

    Abstract : The CTA1-DD/ISCOMs vector is a rationally designed mucosal adjuvant that was developed to host the distinctive properties of either adjuvant alone or in a combination that hosted additive enhancing effects on mucosal immune responses. Here I demonstrate that CTA1-DD can be incorporated into the ISCOM with greatly augmented immunogenicity of both incorporated and admixed antigen. READ MORE

  7. 5. Puumala hantavirus : immune responses and vaccines

    Author : Cristina de Carvalho Nicacio; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hantavirus; Puumala virus; nucleocapsid protein; neutralizing antibodies; Fab fragment; combinatorial library; phage-display; IgA; cellular immunity; cross-protection; intranasal vaccination;

    Abstract : Hantaviruses (family Bunyaviridae) is a group of closely related zoonotic rodent-borne viruses that are transmitted to humans through inhalation of infected rodent excreta. They cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS) with varying degree of severity depending on the causative virus. READ MORE