Search for dissertations about: "isotopic labelling"

Showing result 1 - 5 of 11 swedish dissertations containing the words isotopic labelling.

2. 1. Chemical labelling methods for gel free based proteomics

   Author : Åsa Wåhlander; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biotechnology; Bioteknik; Biokemisk teknik; Biochemical technology; 2D-HPLC; isotopes; labelling; proteomics; mass spectrometry;

   Abstract : In this thesis different aspects of gel free procedures for mass spectrometry based proteome analysis are addressed, with emphasis on labelling techniques. It is based on three original articles where the effects imposed onto peptides upon modification are investigated, and the development of a new type of labelling strategy is described. READ MORE

4. 2. Synthesis of 11C-labelled Alkyl Iodides : Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods

   Author : Jonas Eriksson; Bengt Långström; Philip H. Elsinga; Uppsala universitet; []
   Keywords : Organic chemistry; isotopic labelling; carbon-11; alkyl iodides; acrylamides; specific radioactivity; carbonylation; carbon monoxide; non-thermal plasma; PET; Organisk kemi;

   Abstract : Compounds labelled with 11C (β+, t1/2 = 20.4 min) are used in positron emission tomography (PET), which is a quantitative non-invasive molecular imaging technique. It utilizes computerized reconstruction methods to produce time-resolved images of the radioactivity distribution in living subjects. READ MORE

5. 3. Structural Studies of O-antigen polysaccharides, Synthesis of 13C-labelled Oligosaccharides and Conformational Analysis thereof, using NMR Spectroscopy

   Author : Ulrika Olsson; Göran Widmalm; Corine Sandström; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; conformation; Escherichia coli; lipopolysaccharide; O-antigen; carbohydrates; structure; isotopic labelling; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

   Abstract : In order to understand biological processes, to treat and diagnose diseases, find appropriate vaccines and to prevent the outbreak of epidemics, it is essential to obtain more knowledge about carbohydrate structures. This thesis deals with structure and conformation of carbohydrates, analysed by NMR spectroscopy and MD simulations. READ MORE

6. 4. Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide

   Author : Ola Åberg; Bengt Långström; Nicholas Long; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; [11C]carbon monoxide; isotopic labelling; PET; acrylamide; EGFR; VEGFR-2; 11C; Organic chemistry; Organisk kemi; Organic Chemistry; Organisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

   Abstract : This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C.Two methods for the synthesis of 11C-labelled acrylamides have been explored. READ MORE

7. 5. Transition Metal Mediated Transformations of Carboranes

   Author : Ludvig Eriksson; Kalman Szabo; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; carborane; isoquinoline; PK11195; peripheral bensodiazepine receptor; Cu I Iodide; iodinated carborane; palladium; isotopic exchange; Herrmann’s Catalyst; Heck reaction; Suzuki-Miyaura reaction; cross coupling; arylation; olefination; 125-iodine; radiolabelling; carboraneboronic ester; BNCT; 2-iodo-; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Abstract : This thesis describes the use of copper and palladium to mediate transformations of carboranes, especially p-carborane.1-(1-p-carboranyl)-N-methyl-N-(2-butyl)-3-isoquinolinecarboxamide, a carborane containing analogue of the peripheral benzodiazepine receptor (PBR) ligand PK11195, has been synthesised. READ MORE