Search for dissertations about: "johan staaf"

Found 4 swedish dissertations containing the words johan staaf.

  2. 1. Genomic profiling of breast cancer by microarray-based technology and bioinformatics

    Author : Johan Staaf; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Survival; Prognostic predictor; Gene Expression; ERBB2; HER2; Microarray; Copy Number Analysis; CGH; aCGH; Amplification; Gene expression analysis;

    Abstract : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. READ MORE

  4. 2. Childhood Obesity and Islet Function

    Author : Johan Staaf; Peter Bergsten; Anders Forslund; Hindrik Mulder; Uppsala universitet; []
    Keywords : type 2 diabetes mellitus; Uppsala Longitudinal Study of Childhood Obesity; palmitate; glucose-stimulated insulin secretion; hyperinsulinemia; hyperglucagonemia; GLP-1; glicentin; magnetic resonance imaging; metabolic syndrome; oral glucose tolerance test; centroid; Pediatrik; Pediatrics;

    Abstract : The prevalence of childhood obesity and Type 2 Diabetes Mellitus (T2DM) has increased during recent decades. T2DM is accompanied with functional changes in the islets of Langerhans, which can be identified early in the pathogenesis. READ MORE

  5. 3. Pharmacogenetic biomarkers for chemotherapy-induced adverse drug reactions

    Author : Niclas Björn; Henrik Green; Svante Vikingsson; Joakim Lundeberg; Johan Staaf; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer is a serious disease expected to be the world-leading cause of death in the 21st century. The use of harsh chemotherapies is motivated and accepted but, unfortunately, is often accompanied by severe toxicity and adverse drug reactions (ADRs). READ MORE

  6. 4. Exploring vitamin D and steroid hormone receptors – from healthy elderly to prostate cancer cells

    Author : Maria Araceli Diaz Cruz; Maria Faresjö; Dennis Larsson Dennis Larsson; Johan Staaf; Jönköping University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; vitamin D; steroid hormone receptors; lifestyle; methylation; SNPs; healthy elderly; prostate cancer cells; crosstalk; PDIA3;

    Abstract : The genetic background together with environmental factors and lifestyle are key contributors to the health of an individual. Genetic background is inherited and irreversible unless mutations occur. However, lifestyle habits (i.e. READ MORE