Search for dissertations about: "jorge lira ruas"

Found 1 swedish dissertation containing the words jorge lira ruas.

2. 1. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

   Author : Jorge Lira Ruas; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Hypoxia; HIF-1; protein degradation; transcription; coactivators; CBP; subcellular localization; C1-tetrahydrofolate synthase;

   Abstract : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. READ MORE