Search for dissertations about: "k-ras"

Showing result 1 - 5 of 12 swedish dissertations containing the word k-ras.

  2. 1. Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer

    Author : Annika Wahlström; Göteborgs universitet; []
    Keywords : RCE1; ICMT; K-RAS; CAAX proteins; MPD; lung cancer;

    Abstract : CAAX proteins, such as the RAS and RHO proteins, are recognized by a specific CAAX motif at the carboxyl terminus, which undergoes posttranslational modifications. First, a lipid group is attached to the cysteine (the “C”) of the CAAX motif by farnesyltransferase (FTase) or geranylgeranyltransferase-I (GGTase-I); second, the –AAX are removed by RAS converting enzyme 1 (RCE1); and third, the cysteine is methylated by isoprenylcysteine carboxyl methyltransferase (ICMT). READ MORE

  4. 2. The Importance of Isoprenylation and Nf1 Deficiency in K-RAS-induced Cancer

    Author : Anna-Karin Sjögren; Göteborgs universitet; []
    Keywords : FTase; GGTase-I; isoprenylation; K-RAS; NF1; CAAX proteins; lung cancer; AML;

    Abstract : The RAS and RHO family proteins contribute to tumorigenesis and metastasis and belong to a family of so called CAAX proteins. The membrane targeting and proper function of CAAX proteins are dependent on posttranslational isoprenylation by farnesyltransferase (FTase) or geranylgeranyltransferase type I (GGTase-I). READ MORE

  5. 3. The clinical use of genetic analyses in colorectal cancer

    Author : Susanne Tumlin Ekelund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Colorectal cancer (CRC) is a common global disease, with a mortality rate of almost 50%. Prognosis is mainly based on the TNM classification. Surgical interventions have the potential of being curative in patients with stage I-III CRC. Adjuvant treatment with chemotherapy enhances the survival rate, especially in stage III cancer. READ MORE

  6. 4. On the clinical value of genetic analysis in colorectal cancer patients

    Author : Ulrik Lindforss; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In Sweden, the incidence of colorectal cancer (CRC) is about 5000 new cases every year and this number has not changed markedly during the past twenty years. 90-95% of all CRC appear spontaneously, but there are also inherited forms of CRC (5-10%) of which the two most common are familiar adenomatous polyposis (FAP) and hereditary non-polyposis colorectal carcinoma (HNPCC). READ MORE

  7. 5. Computer-aided drug design approaches in developing anti-cancer inhibitors

    Author : Chunxia Gao; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry;

    Abstract : The thesis entitled “computer-aided drug design approaches in developing anti-cancer drug” is divided into a total of six chapters. In the first chapter, an overview of drug discovery and development are introduced. READ MORE