Search for dissertations about: "knock-out"
Showing result 1 - 5 of 136 swedish dissertations containing the word knock-out.
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1. Knock-out of non-nucleonic components from helium
Abstract : .... READ MORE
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2. Control of metabolism and hormone secretion from pancreatic alpha and beta cells
Abstract : Type 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. READ MORE
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3. The Role of HoxB4 in Hematopoiesis
Abstract : HOXB4 is one of 39 members of the homeobox (HOX) family, a family of transcription factors involved in embryonic development. Several HOX transcription factors, including HOXB4, are highly expressed in hematopoietic stem cells (HSCs) but are downregulated upon differentiation towards more mature progeny cells. READ MORE
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4. Functional analysis of the mouse J chain
Abstract : We have in this study analyzed the function of the murine Joining chain (J chain) in vivo. J chain is a polypeptide found in sera and secretions in complex with pentameric IgM and dimeric IgA. READ MORE
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5. LXR and aromatase knock-out mice : animal models providing insight into human diseases
Abstract : In our characterization of mouse strains carrying mutations in nuclear receptor and aromatase genes we have found phenotypes which resemble four human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome (SS), amyotrophic lateral sclerosis (ALS), and exocrine pancreatic insufficiency. The work in this thesis was designed to understand the roles of LXRalpha, LXRbeta and aromatase in development of these diseases and to investigate whether these animal models help us (1) to understand the etiology of the corresponding human diseases and (2) to develop new therapeutic approaches for the treatment of these diseases. READ MORE