Search for dissertations about: "lactam analogs"

Found 3 swedish dissertations containing the words lactam analogs.

  2. 1. Synthetic analogs of sialyl Lewis x

    Author : Ulf Ellervik; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; stereoselective synthesis; regioselective synthesis; lactam analogs; lactone; Selectin; Sialyl Lewis x; SLex; Organic chemistry; Organisk kemi;

    Abstract : The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. READ MORE

  4. 2. Synthesis of Conformationally Restricted Oligosaccharides

    Author : Michael Wilstermann; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Streptococcus suis; E. coli; neoglycolipid; ganglioside-lactam; xylose; methylene acetal; sialic acid; Conformational Restriction; galabiose; Organic chemistry; Organisk kemi;

    Abstract : Gangliosides are sialic acid-containing glycosphingolipids that often are present in increased amounts on tumor cells. Since the gangliosides are hydroxy-acids, they can form lactones. The lactones have been suspected to be more immunogenic than the open forms, but are in practise poor immunogens due to their ease of hydrolysis. READ MORE

  5. 3. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor

    Author : Jens Lindman; Mats Larhed; Johan Gising; Christian Sköld; Alessandra Tolomelli; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Mizoroki-Heck reaction; spiroindolines; spirooxindoles; amino acids; carbonylation; angiotensin II type 2 receptor; AT2R ligands; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. READ MORE