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Showing result 1 - 5 of 6 swedish dissertations matching the above criteria.

  2. 1. Effects of some Endocrine Disruptors on Human and Grey Seal Uterine Cells

    Author : Carolina Bredhult; Matts Olovsson; Britt-Marie Bäcklin; Olle Söder; Uppsala universitet; []
    Keywords : Obstetrics and gynaecology; Reproductive toxicology; Baltic grey seal; leiomyoma; myometrial cells; endometrial endothelial cells; hormones; endocrine disruptors; Obstetrik och kvinnosjukdomar;

    Abstract : The effects of environmental contaminants in humans and animals are of great concern. Some contaminants are endocrine disruptors that may interfere with the endogenous hormonal signalling and disturb, for example, reproductive organs and functions. READ MORE

  4. 2. Mifepristone for preoperative treatment of uterine leiomyoma

    Author : Mikael Engman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : AIM: To explore the clinical impact and its molecular regulation on uterine leiomyomas in preoperative treatment with mifepristone, a progesterone receptor modulator (PRM). BACKGROUND: Uterine leiomyomas are highly prevalent in fertile women, increasing with age up to 35-50 % in a population approaching the age of 50. READ MORE

  5. 3. Hormonal regulation of sex steroid receptors and growth related genes in human myometrium and leiomyomas

    Author : Katarina Englund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Uterus; leiomyoma; steroid receptor; protooncogenes; IGF-I; EGF.;

    Abstract : Uterine fibroids, or leiomyomas, are the most common benign tumors in the female genital tract.They represent a major cause of gynaecologic morbidity. The etiology of these tumors is largely unknown but the levels of estrogen (E) and progesterone (P) are considered to be the major determinants for fibroid growth. READ MORE

  6. 4. Regulatory importance of cyclic nucleotides in smooth muscle growth of the urogenital tract

    Author : Per Adolfsson; Thoralf Christoffersen; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Smooth muscle hyperplasia/hypertrophy is, if not responsible for, so at least involved in those diseases, which impair life quality for most people in today's society.This thesis, presents a pharmacological investigation, related to the regulatory role of cyclic nucleotides, of smooth muscle hyperplasia/hypeitrophy in human uterine leiomyoma and benign prostate hyperplasia (BPH). READ MORE

  7. 5. Molecular mechanisms involved in the growth of human uterine leiomyomas

    Author : Xuxia Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Human uterine leiomyomas; myometrium; the menstrual cycle; estrogen; progesterone; cellular proliferation; apoptosis; oncogene; growth factor; growth factor receptor.;

    Abstract : Human uterine leiomyomas (fibroids) are benign neoplasms arising from uterine smooth muscle cells, and are suggested to be sex steroid dependent. The aim of this study was to investigate the molecular mechanisms by which sex steroids, mainly estrogen and progesterone, influence the growth of Ieiomyomas. READ MORE