Search for dissertations about: "ligand-gated ion channel"

Showing result 1 - 5 of 11 swedish dissertations containing the words ligand-gated ion channel.

  1. 1. Studies of ligand- and temperature-gated ion channels using microfluidic methods

    University dissertation from Chalmers University of Technology

    Author : Maria Millingen; Chalmers tekniska högskola.; Chalmers University of Technology.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurokemi; Neurochemistry; Biofysikalisk kemi; Biophysical chemistry; ion channel; GABAA receptor; TRPV1; microfluidics; solution exchange; desensitization; temperature control; ligand-gated; temperature-gated;

    Abstract : This thesis describes the studies of the GABAA receptor, a ligand-gated ion channel, and the ligand- and temperature-gated ion channel TRPV1. The desensitization behavior of both of these proteins has been studied for different conditions, using a microfluidic device for superfusion. READ MORE

  2. 2. Revealing Secrets of Synaptic Protein Interactions A Biosensor based Strategy

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Christian Seeger; Uppsala universitet.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surface plasmon resonance; biosensor; AMPA receptor; GABAA receptor; ligand-gated ion channel; A-kinase anchoring protein; caldendrin; calmodulin; HIV; fragment based drug discovery; Biokemi; Biochemistry; Neuroscience; Neurovetenskap;

    Abstract : Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. READ MORE

  3. 3. Patch-clamp studies of the GABAA receptor using microfluidic methods

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Millingen; Chalmers tekniska högskola.; Chalmers University of Technology.; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biologi; Biology; Kemi; Chemistry; Bioteknik; Bioengineering; ion channel; microfluidics; GABAA receptor;

    Abstract : Ion channels are membrane proteins that passively transport ions. When activated, conformational changes within the protein lead to opening of a channel pore, and the flow of ions causes a change in the membrane potential. This is the fundamental process behind the generation and transduction of nerve impulses. READ MORE

  4. 4. Advanced Fluorescence Microscopy to Study Plasma Membrane Protein Dynamics

    University dissertation from Lausanne : EPFL

    Author : Joachim Piguet; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fluorescence; microscopy; plasma membrane; membrane proteins; membrane proteins diffusion; single-molecule imaging; single-molecule tracking; pentameric ligand-gated ion channels; nicotinic acetylcholine receptor; serotonin receptor; synapse; neuromuscular junction; post-synaptic scaffold; rapsyn; myopathies; fluorescent proteins; Förster resonance energy transfer; FRET imaging; protein-protein interactions; protein trafficking; photo-activatable proteins; Biologisk fysik; Biological Physics;

    Abstract : Membrane protein dynamics is of great importance for living organisms. The precise localization of proteins composing a synapse on the membrane facing a nerve terminus is essential for proper functioning of the nervous system. In muscle fibers, the nicotinic acetylcholine is densely packed under the motor nerve termini. READ MORE

  5. 5. Ion channels in drug discovery : Focus on biological assays

    University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

    Author : Kim Dekermendjian; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

    Abstract : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. READ MORE