Search for dissertations about: "ligand-gated"

Showing result 1 - 5 of 21 swedish dissertations containing the word ligand-gated.

2. 1. Combining low resolution, high resolution, functional, and simulation techniques : In the study of pentameric ligand-gated ion channels

   Author : Marie Lycksell; Erik Lindahl; Kresten Lindorff-Larsen; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Neutrons; Small-angle scattering; Cryo-EM; Simulations; Ion channels; Biophysics; biofysik;

   Abstract : Combining methods yielding different information is a powerful approach for understanding structural biology in general, and in particular systems such as pentameric ligand-gated ion channels (pLGICs). Pentameric ligand-gated ion channels are membrane proteins that sense chemical signals, which they convert to changes in membrane potential. READ MORE

4. 2. Studies of ligand- and temperature-gated ion channels using microfluidic methods

   Author : Maria Millingen; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; solution exchange; desensitization; temperature-gated; ion channel; temperature control; ligand-gated; TRPV1; GABAA receptor; microfluidics;

   Abstract : This thesis describes the studies of the GABAA receptor, a ligand-gated ion channel, and the ligand- and temperature-gated ion channel TRPV1. The desensitization behavior of both of these proteins has been studied for different conditions, using a microfluidic device for superfusion. READ MORE

5. 3. Allosteric modulation of pentameric ligand-gated ion channels by general anesthetics

   Author : Stephanie A. Heusser; Erik Lindahl; Pierre-Jean Corringer; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

   Abstract : Pentameric ligand-gated ion channels (pLGICs) are key components of fast synaptic transmission and are targets of neuroactive drugs such as benzodiazepines, alcohol and muscle relaxants. Although early theories of general anesthesia suggested non-specific lipid interaction as the mechanism of anesthetic action, it has now become evident that they too bind to pLGICs. READ MORE

6. 4. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels

   Author : Yuxuan Zhuang; Erik Lindahl; Grace Brannigan; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ion channels; molecular dynamics; markov state model; lipid modulation; nicotinic receptor; protein conformational transitions; Biophysics; biofysik;

   Abstract : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. READ MORE

7. 5. Revealing Secrets of Synaptic Protein Interactions : A Biosensor based Strategy

   Author : Christian Seeger; U Helena Danielson; Sarah Lummis; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surface plasmon resonance; biosensor; AMPA receptor; GABAA receptor; ligand-gated ion channel; A-kinase anchoring protein; caldendrin; calmodulin; HIV; fragment based drug discovery; Biokemi; Biochemistry; Neuroscience; Neurovetenskap;

   Abstract : Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. READ MORE