Search for dissertations about: "lineage commitment"

Showing result 1 - 5 of 54 swedish dissertations containing the words lineage commitment.

  2. 1. Lineage commitment to a T

    Author : Sidinh Luc; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cell; hematopoiesis; lineage commitment; lymphoid-primed multipotent progenitor;

    Abstract : he hematopoietic development is a highly dynamic but tightly regulated process. The flexibility to produce blood cells through more than one route will allow the blood system to respond rapidly in stress situations such as infections. READ MORE

  4. 2. Cellular pathways and molecular regulation of hematopoietic stem cells

    Author : Kristina Anderson; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-catenin.; lineage commitment; hematopoietic stem cells; lineage priming; Wnt signaling pathway; biphenotypic cells; PAX5;

    Abstract : Hematopoietic stem cells (HSCs) are defined by their unique properties to self-renew and differentiate into all hematopoietic cell lineages. Residing in the bone marrow (BM), adult HSCs are organized in a hierarchy of cells that differ in their self-renewal and proliferative capacity. READ MORE

  5. 3. Maintenance and Commitment of Hematopoietic Progenitors: Role of flt3, c-kit and c-mpl

    Author : Ole Johan Borge; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KL; hematopoiesis; FL; cytokines; B-cells; commitment; flt3; differentiation; Haematology; IL-7; c-kit; progenitors; Hematologi; stem cells; thrombopoietin; viability; extracellular fluids; extracellulära vätskor;

    Abstract : The need for red blood cells to transport oxygen and CO2, blood platelets to stop bleedings, and neutrophils, macrophages, B- and T-cells for host defense, is a prerequisite for life. These mature blood cells have a limited life span and are thus constantly replenished by an enormous cell production (estimated to 1012 cells per day) which primarily takes place in the bone marrow (BM). READ MORE

  6. 4. The Road to Maturity - Lineage Commitment in early Hematopoiesis

    Author : Charlotta Böiers; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The road to maturity – how do hematopoietic stem cells (HSC) differentiate into mature blood cells? The pathways of lineage commitment during normal hematopoiesis are of great significance in order to understand the underlying events that lead to leukemia, and to the design of proper treatments for prevention and remission of the disease. The route of hematopoiesis can be thought of as a hierarchical tree, with the rare HSCs at the top, transitioning down along the pathways as different progenitors. READ MORE

  7. 5. Molecular mechanisms in lymphoid restriction : securing the B lineage fate

    Author : Josefine Åhsberg; Mikael Sigvardsson; Jan-Ingvar Jönsson; Charles G. Mullighan; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : With the work in this thesis I have aimed to deepen the understanding of the mechanisms behind the development of different blood cell lineages with a specific focus on B cell development.To understand the interplay between extracellular signaling and transcription factor networks in early lymphoid development we investigated the functional collaborations of FLT3 and IL7R. READ MORE