Search for dissertations about: "linkage analysis"

Showing result 16 - 20 of 295 swedish dissertations containing the words linkage analysis.

  2. 16. On the genetics of hereditary breast/ovarian cancer. BRCA1, BRCA2 and beyond

    Author : Annika Bergman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BRCA1; BRCA2; breast cancer; hereditary cancer; founder mutation; mutation analysis; linkage analysis; genome scan; BRCAX;

    Abstract : Breast cancer is the most common malignancy in women. Most of the breast cancers are sporadic with no apparent inheritance factor but about 5-10% is believed to be caused by an inherited predisposition. Aims: This thesis aimed at defining the BRCA1/2 mutation spectrum of the west Swedish population and specifically to characterize the BRCA1c. READ MORE

  4. 17. Linkage and association analysis in multiple sclerosis

    Author : Yamei Dai; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which is characterized by relapsing or progressive demyelinating plaques in the brain and spinal cord. It is well established that complex genetic factors influence susceptibility to MS. READ MORE

  5. 18. Genetic and Molecular analysis of the Spinocerebellar ataxia type 7 (SCA7) disease gene

    Author : Jenni Jonasson; Monica Holmberg; Christine Van Broeckhoven; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Spinocerebellar ataxia; human genetics; linkage analysis; anticipation; CAG repeat expansion; founder effect; protein expression; ATXN7; Medical genetics; Medicinsk genetik;

    Abstract : Spinocerebellar ataxia type 7 (SCA7) is a hereditary neurodegenerative disorder affecting the cerebellum, pons and retina. SCA7 patients present with gait ataxia and visual impairment as the main symptoms. READ MORE

  6. 19. Chicken Genomics - Linkage and QTL mapping

    Author : Per Wahlberg; Leif Andersson; Ruedi Fries; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; chicken; quantitative genetics; linkage map; QTL mapping; recombination; long-term selection; Z chromosome; selective sweep; SNP; Genetics; Genetik;

    Abstract : This thesis presents results from genetic studies conducted in the chicken (Gallus gallus). The domestication of chicken is believed to have been initiated approximately 7,000 – 9,000 years ago in Southeast Asia. READ MORE

  7. 20. Political Representation in the European Union : A Multi-Channel Approach

    Author : Moa Mårtensson; Christer Karlsson; Sverker Gustavsson; Torsten Svensson; Hans Agné; Uppsala universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; political representation; EU; multi-channel approach; European Parliament; Council of Ministers; interest representation; linkage; Services Directive; social-network analysis; coordination; Statskunskap; Political Science;

    Abstract : The European Union (EU) is the most far-reaching attempt yet undertaken to institutionalize democratic policy-making beyond the nation-state. To what extent, and in what ways, do various channels of representation contribute towards the realization of this aim? This dissertation takes stock of current research on the EU’s system of representation, and seeks to expand its agenda so that this central question can be properly addressed. READ MORE