Search for dissertations about: "liposome drug delivery thesis"

Showing result 1 - 5 of 8 swedish dissertations containing the words liposome drug delivery thesis.

  1. 1. Liposomes for Drug Delivery from Physico-chemical Studies to Applications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nill Bergstrand; Uppsala universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; liposome; steric stabilisation; BNCT; cryo-TEM; EGF; targeting; stability; permeability; pH-sensitive liposomes; triggered release; Fysikalisk kemi; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Abstract : Physico-chemical characterisation of structure and stability of liposomes intended for drug delivery is the central issue in this thesis. In addition, targeted liposomes to be used in boron neutron capture therapy (BNCT) were developed.Lysolipids and fatty acids are products formed upon hydrolysis of PC-lipids. READ MORE

  2. 2. Sterically stabilised liposomes and related lipid aggregates Fundamental studies on aggragate structure and stability

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Johnsson; Uppsala universitet.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; liposome; steric stabilisation; colloidal stability; cryo-TEM; drug delivery; Fysik; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik; Physical Chemistry; fysikalisk kemi;

    Abstract : Various aspects of and approaches towards the steric stabilisation of liposomes have been investigated, mainly by use of fluorescence techniques and cryo-transmission electron microscopy (cryo-TEM). It is shown that PEG(2000)-lipids can be incorporated in the liposome membrane up to a critical concentration of 8-10 mol% without any observable structural perturbations. READ MORE

  3. 3. Physico-Chemical Investigations of Bilayer Discs and Related Lipid Structures Formed in Liposomal Systems Intended for Triggered Release

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Sandström; Uppsala universitet.; [2007]
    Keywords : Physical chemistry; liposome; triggered release; pH-sensitive liposomes; temperature-sensitive liposomes; drug partitioning; cryo-TEM; discs; Fysikalisk kemi;

    Abstract : This thesis describes results from fundamental studies of liposomes intended for drug delivery and pH or temperature triggered release. In addition, the effect of lipid composition on bilayer disc formation and a potential application of the bilayer discs were investigated. READ MORE

  4. 4. Hyperthermia-responsive liposomal systems

    University dissertation from Chalmers University of Technology

    Author : Yujia Jing; Chalmers tekniska högskola.; Chalmers University of Technology.; Chalmers tekniska högskola.; Chalmers University of Technology.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug delivery; supported lipid membranes; liposomes; phospholipase; asymmetry; phase transition; flip-flop; hyperthermia; cationic lipid;

    Abstract : Abstract Sophisticated liposomal systems are emerging at an increasing rate to meet the demands for multifunctional drug carriers in chemotherapies in combined with hyperthermia. For example, liposomal drug carriers for temperature-controlled drug release under hyperthermic conditions have recently been tested in clinical trials. READ MORE

  5. 5. Towards specific quantification of exosomes using surface-based sensing

    University dissertation from Chalmers University of Technology

    Author : Déborah L. M. Rupert; Chalmers tekniska högskola.; Chalmers University of Technology.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibody; binding rate; cluster of differentiation 63 CD63 ; concentration; diffusion; mass transport limited conditions; exosome; extracellular vesicles; label-free; liposome; nanoparticle tracking analysis; quantification; specific detection; surface-based biosensor; surface plasmon resonance.;

    Abstract : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. READ MORE