Search for dissertations about: "liposome drug delivery thesis"

Found 5 swedish dissertations containing the words liposome drug delivery thesis.

  1. 1. Liposomes for Drug Delivery from Physico-chemical Studies to Applications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nill Bergstrand; Uppsala universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; liposome; steric stabilisation; BNCT; cryo-TEM; EGF; targeting; stability; permeability; pH-sensitive liposomes; triggered release; Fysikalisk kemi; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Abstract : Physico-chemical characterisation of structure and stability of liposomes intended for drug delivery is the central issue in this thesis. In addition, targeted liposomes to be used in boron neutron capture therapy (BNCT) were developed.Lysolipids and fatty acids are products formed upon hydrolysis of PC-lipids. READ MORE

  2. 2. Sterically stabilised liposomes and related lipid aggregates Fundamental studies on aggragate structure and stability

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Johnsson; Uppsala universitet.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; liposome; steric stabilisation; colloidal stability; cryo-TEM; drug delivery; Fysik; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik; Physical Chemistry; fysikalisk kemi;

    Abstract : Various aspects of and approaches towards the steric stabilisation of liposomes have been investigated, mainly by use of fluorescence techniques and cryo-transmission electron microscopy (cryo-TEM). It is shown that PEG(2000)-lipids can be incorporated in the liposome membrane up to a critical concentration of 8-10 mol% without any observable structural perturbations. READ MORE

  3. 3. Physico-Chemical Investigations of Bilayer Discs and Related Lipid Structures Formed in Liposomal Systems Intended for Triggered Release

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Sandström; Uppsala universitet.; [2007]
    Keywords : Physical chemistry; liposome; triggered release; pH-sensitive liposomes; temperature-sensitive liposomes; drug partitioning; cryo-TEM; discs; Fysikalisk kemi;

    Abstract : This thesis describes results from fundamental studies of liposomes intended for drug delivery and pH or temperature triggered release. In addition, the effect of lipid composition on bilayer disc formation and a potential application of the bilayer discs were investigated. READ MORE

  4. 4. Membrane-mimetic systems Novel methods and results from studies of respiratory enzymes

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Gustav Nordlund; Stockholms universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lipids; membrane proteins; method development; respiration; reconstitution; supported membranes; SNAREs; liposome fusion; lipid-protein interactions; biokemi; Biochemistry;

    Abstract : The processes localized to biological membranes are of great interest, both from a scientific and pharmaceutical point of view. Understanding aspects such as the detailed mechanism and regulation of these processes requires investigation of the structure and function of the membrane-bound proteins in which they take place. READ MORE

  5. 5. Two-Step Targeting for Effective Radionuclide Therapy Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Amelie Fondell; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide; Auger electrons; liposomes; targeting; tumour therapy; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. READ MORE